TolC Gene in Salmonella - Essay Example

TolC is considered a superficial casing conduit. This gene is involved in the secretion of different kinds of particles such as antibiotics in Escherichia coli. Other substances that are secreted by the TolC gene include macrobiotic solvents, and a number of antiseptic peptides (Tegos and Mylonakis, 2012). TolC functions hand in hand with other internal casing mediums in a bid to expunge unwanted elements. Research done over the recent past has posited that a number of mechanisms accountable for dissipating noxious substances from the E. coli cell require the presence of TolC in order to function properly (Yu, Zhang, and Brown, 2013).

            This function directly relates to the intracellular pathogenesis in salmonella. According to Toone, (2011), the absence of TolC in salmonella as a result of its removal elevates the level of defencelessness or vulnerability of salmonella to the various agents that exterminate or eradicates bacteria, viruses, and other germs, and also chemical composites. It is however important to elucidate the fact that in salmonella, TolC relies on other mechanisms for accountable for the removal of noxious substances from the cells. According to Horiyama, Yamagichi and Nishino (2010), these other mechanisms include "AcrAB, AcrD, AcrEF, MdtABC, MdsAB, EmrAB, and MdfA, MacAB, and MdtK" (p. 1372). In a nutshell, the function of the TolC gene in salmonella is aiding in the secretion of noxious substances from the cells of salmonella.