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The invitro effect of sildenafil citrate on the outcome of pregnancy in mice and offsprings
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The Invitro Effect of Sildenafil Citrate on the Outcome of Pregnancy in Mice and Offspring Student’s Name: Student ID Number: Course Title Code: PhD Embryology. Date: Infertility is the inability of a woman to conceive a baby after a year of progress unprotected sex (Zegers-Hochschild et al, 2009)…
Other medications that can be put to use to make infertile women conceive a baby includes the controlled ovarian stimulation, intrauterine insemination (IUI), and ovulation induction. Although the use of ART can result to a successful pregnancy, not all women who undergo ART can become pregnant. Infertility may occur in all types of species; whether human or animals. This chapter tries to investigate the expression of PDE5 in the pre-implantation embryos and the effect of sildenafil citrate (Viagra) on pre-implantation murine embryo development in vitro. Sildenafil is a special drug with a nitric oxide effects on vascular smooth muscles. Randomly selected mice were divided into two groups. One group was hyper stimulated group whereas the other was hyper stimulated plus sildenafil citrate group. The mice were injected with human menopausal gonadotropin (HMG), and later they received human chorionic gonadotropic (HCG) hormones. Afterwards, two female mice were put in one cage with one male mouse for mating process (Rashidi, Rad, Roshangar, & Mira, 2012). ...
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