Nitric Oxide Production in Cytokine Activated Macrophages
, Lab Report
...Activated Macrophages Background Microphages play a key role in the regulation of adaptive and innate immune responses via intracellular and phagocytosis digestion of apoptotic cells, microorganisms, and inflammatory byproducts, and the secretion of chemokine, cytokines, and reaction nitrogen and oxygen intermediates (Albina, 1993). Simulation of the macrophages with the cytokines such as IFN-γ, IL-1α, IL-1β, TNF-β, IL-6, and TNF-α, which are secreted during various processes of immune responses, result in synthesis of NO (NOS). NOS causes the macrophages to become cytotoxic against tumor cells, microorganisms, and normal cells (Chong, 2005). Apoptosis plays... Nitric Oxide Production in Cytokine...