This paper stresses that in many years following the first successful transplantation of organs, preservation of tissues and organs has attained incredible successes in enhancing and improving preservation and function of organs, and irrespective of these improvements, a huge disparity still exists among the number of people on the waiting list and the available organs donors. The main organ preservation challenge will be how to enhance the marginal donor organs recovery and resuscitation mainly the donation after cardiac organ death; therefore, given the success of static organ preservation methods, the dynamic preservation methods, oxygen persufflation methods and other methods, there is a crucial advances in improving the donor problems. The author of the paper talks that dynamic preservation methods require some dynamic fluid or gas movement to allow preservation. In the 20th century, Hypothermic machine perfusion was invented for organ preservation to extend both preservation time and quality.
This report makes a conclusion that hypothermic machine perfusion allows organs oxidation for ATP creation through fluid perfusion for oxygen transportation. The cold tissues oxygen requirements are low thus the oxygen demand is also low and this allows for slow flow rates during hypothermia and the relatively low oxygen carrying capacity of most crystalloid perforates are adequate at low temperatures. ...Show more