Clifton et al. (2008) therefore sought to investigate the long-term effects of high-protein diets (HP) on weight loss maintenance, bone health markers and cardiovascular disease risk factors.
2 – Methodology: The study was based on an intensive 12-week long weight loss program followed by a 52-week follow-up study on seventy-nine healthy women with a mean age of 49 (± 9) years. The study was based on a parallel design in which the subjects were randomly divided into two groups, one with a high protein (HP) diet and the other with a high carbohydrate diet (HC). Body weight, BMI, plasma glucose, serum total cholesterol, insulin, C-reactive protein and other disease biomarkers were measured during the intervention and in follow-up studies. The dietary record during follow-up was based on self-reported data on food intake.
3 – Result: The mean weight loss for the HP group was 4.6 ± 5.5 kg while it was 4.4 ± 6.1 kg for the HC group. The difference in weight loss between both the groups was statistically insignificant. There was an increase in HDL cholesterol in both the groups. Variations in lipid, insulin, C-reactive protein, glucose, folate and homocysteine levels were not significantly different between the two groups. Higher levels of vitamin B-12 were found in those with the HP dietary intervention.
4 – Discussion: Though the differences in weight loss between the two groups (HP and HC diets) were found to be statistically insignificant, multiple regression analysis was conducted on all subjects, collectively as one intervention group, to further ascertain the effects of HC and HP diets. This analysis revealed that while weight loss is greater in subjects who consume higher protein diets, carbohydrate intake was a better predictor of reduction in abdominal and total fat. The reduction in disease biomarkers and risk factors was related to the beneficial effects of weight loss that resulted from a HP diet rather than the HP ...
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