Clinical neural scaffold for olfactory ensheathing cells

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Chapter 14 Sterilization and Surface Functionalization 14.1 Sterilization Effect on Fibre Morphology The relative susceptibility to the PLGA and PMMA to the chemical and irradiation steps involved in the sterilization process was studied. The sterilization of fibre mesh mounted membrane insert under three conditions was investigated to determine the effect of each mechanism individually.


It is known that UV can degrade polymer. Previous studies showed that UV wavelength of 250 nm can cleave poly (methyl methacrylate), a standard polymer to its monomer methyl methacrylate and gases (Srinivasan, Braren, & Casey, 1990). Increasing the duration of the sterilization also increased damage to the polymer structure (Shearer, Ellis, Perera, & Chaudhuri, 2005)Recently, UV has been shown to induce significant degradation of PLGC and P(LLA-CL) nanofibers (Yixiang, Yong, Liao, Chan, & Ramakrishna, 2008). The degradation by UV of electrospun nanofibers can be exploited for the fabrication of 3D nanofibrous scaffolds with micropores. For the ethanol sterilization, the global structure of the fibrous mesh shrank in size, detaching part of the fastened portion of the mesh from the membrane insert Investigation on two different scaffolds showed that ethanol sterilization also resulted in damage to the polymer (Shearer, Ellis, Perera, & Chaudhuri, 2005). Digital image analysis from SEM images, showed that average fibre diameter expanded by 21.1% (EOa= 1.08µm; EOb=0.89 µm) (Error: Reference source not found). ...
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