This phenomenon reduces the risk of heart diseases but at the same time HDL also stimulates migration and activates signal transduction pathways in the human breast cancer cell lines, thus acting like a catalyst in the development of breast cancer. Thus knocking down the HDL receptor, SR-BI by some pharmacological methodologies play an essential role in regulating cellular proliferation and migration, thus controlling the growth of tumor cells, and hence SR-BI can be essentially used in the treatment of breast cancer in humans. The Popular article, Good cholesterol and breast cancer risk explains about the above detailed primary research article in a crisp manner. Though HDL that is, good cholesterol is good for health and acts like a protective shield against heart disorders, it has a negative impact on breast cancer development in humans. Higher the level of HDL in blood, higher is the risk of developing breast cancer. Thus limiting the HDL receptor, SR-BI the rapid proliferation of tumor cells were found to be greatly reduced. The popular article also interacts with Dr. Philippe Frank, head of the research team and a cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University who stresses on the importance of inventing more specific drugs to inhibit SR- BI and the safer level of HDL to be mentioned in cancer patients. How it relates to the theme – ‘Gender, Science and Technology’ Both the articles are interlinked and have a strong correlation with the theme of ‘Gender, Science and Technology’. The main focus of both the articles is about the treatment for breast cancer. Though the exact cause for breast cancer is still a topic under research, analysing the risk factors can show who is most likely to develop the disease. Lifestyle choices, genetic disorders and medications taken for some kind of diseases may be some of the risk factors for developing the disease but some risk factors are more vulnerable, particularly one’s ‘Gender’. Breast cancer is most common in women because they have more breast tissue than men. Breast cancer causes include what stimulates the breast tissue to grow and develop. Female relatives can also be a risk factor for getting breast cancer. If one’s mother, sister or daughter have breast cancer, the chances of getting the disease is doubled. Though cancer of several types is the leading cause of death in the world, medical science and technology has empowered people to make life changing decisions by matching them with modern and advanced treatment options based on individual conditions of the patients. Modern science and technology has revolutionized the breast cancer research therapies and now chances of overcoming breast cancer are much better than in earlier days. Main Scientific Claim The authors claim that their examination about the role of HDL and SR-BI in the regulation of cellular signalling pathways in breast cancer cell lines and development of tumors show that, HDL can stimulate the signal transduction pathways in the human breast cancer cell lines. Then, accelerate the formation of tumors and hence knocking down of HDL receptor, SR-BI limits the
Gender, Science and Technology Primary science article and Popular article – Summaries The primary science article, Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development, written by Christiane Danilo, Jorge L Gutierrez-Pajares, Maria Antonietta Mainieri, Isabelle Mercier, Michael P Lisanti and Philippe G Frank, explains the role of Scavenger receptor Class B Type I (SR-BI) in breast cancer development…
Breast cancer is the more common type cancer among American women and is one of the leading causes of death in the United States (Weaver, 2007). For instance, in 2007, experts estimated placed at 240,000 people, including men, who will be victims of cancer in the United States for that year (Weaver, 2007).
According to the research findings it can therefore be said that breast cancer is an important malignancy in women because of its high incidence. The signs and symptoms of breast cancer are important to be understood by women as the early detection of the tumor plays an important role in better prognosis.
Breast cancer has got many risk factors. The majority cases of breast cancer are reported among women who are above 50 years. The cancer is known to occur is families with a history of the cancer (National Cancer Institute, 4). It is also common in the late cases of the first pregnancy and among kinsfolk with a history of benign breasts ailments and diseases.
There are many types of cancer. As the name indicates, cancer cells are produced in the breast part with the possibility of affecting other organs and tissues of the human body. Cells are the basic elements that create tissues in the body. Research (McPhee & Tierney, 2007, pp.
The RNA polymerase needs other proteins in order to carry out the transcription process. Ensuring that transcription is adequately and properly carried out helps ensure cell growth and metabolism. Recently emerging studies point out that some adult cells may be affected and transformed into stem cells when a small number of transcription factors are added in (Takahashi and Yamanaka, 2006).
It contains many cancer causing chemicals, and almost one third of all cancer deaths are related to tobacco use. Tobacco smoking has generally been considered to have little or no association with breast cancer risk. Newer
Ethnic specific mutations of BRCA1 and BRCA2 are found in Ashkenazi (European) Jewish origin and in some families in Iceland, the Netherlands, and the Balkans. American Cancer Society has reported that breast cancer related deaths are
Estrogen is the hormone which supports the breast cancer to grow rapidly, but what actually causes breast cancer, is still a debate. However, hormones do play a big role in the growth of breast cancer. Studies have shown that breast cancer rate is high in those people
On the positive side, advanced treatment and drugs available for breast cancer, are saving many women’s lives and they are able to resume their normal life with minor ‘alterations’. Also, early detection can cure the woman in an effective
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