In insulin dependent patients with type 2 diabetes, especially with obesity, control of glycemia is a challenging issue (Hood et al, 2006). Intensification of insulin therapy to achieve target levels of glycosylated hemoglobin leads to further weight gain. Infact, one of main anxieties with insulin therapy in this population is poor weight gain (Nayak et al, 2010). In several developed countries like UK, there are recommendations for obesity surgery, along with exercise, diet and drug control of diabetes. However, obesity surgery is associated with significant risk. Exenatide, when given as an adjunct to insulin therapy, has been proven to not only achieve better control of blood glucose levels, but also decrease the chances of gaining weight. Infact, some studies have demonstrated weight loss with exenatide therapy. In this article, evidence to support the prescription of exenatide, as an adjunct to insulin therapy will be discussed through review of suitable literature.
Understanding the pathophysiology and treatment basis of diabetes type-2
Diabetes mellitus can be defined as a group of clinical syndromes characterized by hyperglycemia arising as a result of absolute or relative insulin deficiency (Edwards et al, 2002). There are basically 2 types of diabetes mellitus. ...Show more