EBP: Research Application - Article Example


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EBP: Research Application

Moreover, it critically analyses the recommendations made by the authors in light of the current guidelines regarding the management of GERD amongst infants. Winter et al. (2010) conducted a multicenter, randomized, treatment-withdrawal study, which concluded that the short term use of proton pump inhibitors such as Pantoprazole was safe and efficacious, demonstrated by the improvement in the weekly GERD symptom score (WGSS), for the management of symptoms of Gastroesophageal Reflux Disease or GERD, as it is commonly referred to as, amongst infants aged 1 to 11 months (Winter, et al., 2010). The findings of this study are important as it is the first multicenter, randomized, placebo-controlled study of its kind to validate the safety and efficacy of Pantoprazole, a proton pump inhibitor (PPI), in the treatment of GERD, which was previously only demonstrated in small clinical trials (Winter, et al., 2010). ...
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Efficacy and Safety of Pantoprazole Delayed-release Granules for Oral Suspension in a Placebo-controlled, Treatment-withdrawal Study in Infants 1–11 Months Old with Symptomatic GERD. Newborns and infants commonly encounter gastroesophageal reflux, which is asymptomatic in the majority of patients and is generally considered a physiologic phenomenon, but when it does give rise to symptoms, such as vomiting, dysphagia, hematemesis and anemia, it can be a source of great distress and morbidity for the infants (Winter, et al., 2010)…
Author : kebert
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