Name Subject Date Clonidine against Pain Introduction Pain is a serious alarm of the organism informing about damaging of tissues. To take control over pain and to deal with it, different researchers and scientists provided patients with a great care, but, of course, medical treatment was necessary too…
Of course, physicians can provide aggressive pain management, but it is better to find both effective and less damaging solutions to treat the organisms of the patients appropriately (Bergendahl, Lonnqvisy, Eksborg, Ruthstrom, Nordenberg, Bianchi, Ginggen, Tardy 2008, p. 973). Numerous researches and studies of the modernity are devoted to the discussion about the usage of clonidine in medical treatment. In spite of the fact that the majority of researches were devoted to the involvement of this drug in the field of hypertension treatment a lacking of attention is paid to usage of clonidine for pain treatment. Heroin or similar drugs can be found as alternative for the people suffering from chronic pain. When a patient is treated with clonidine in the process of heroine abuse relief, or when detoxification of the organism occurs a physical discomfort can be released. Clonidine in medicine: literature review There are different forms of this medication. An option to use a pain-release tablet is appropriate for the patients with a long-term pain. In this case a tablet brings an essential relief. Clonidine can be also given to cancer patients and it is provided in the form of an epidural. It is possible to combine clonidine with morphine (Amany&Ashraf 2012, p. 8). Another article is devoted to the problem of clonidine usage for chronic low back pain (LBP). The usage of clonidine can be effective and improve motor function. In this research it was found out that: “the addition of low-dose systemic clonidine improves therapeutic outcome in measures of both axial and radiating pain. Combination therapy could be of enormous benefit to patients suffering from chronic LBP” (Tajerian, Millecamps, Stone 2012, p. 150843).Clonidine is alpha-agonist direct actor. There are some essential negative outcomes after using clonidine for pain release, when (35%) of patients suffered from sedation orlethargy; became anxious, agitated, depressed, experienced insomnia etc. The principle of clonidine operation is thenoradrenergic basis (Miller, Miller, Jolley 2001, p. 1227). This study revealed that clonidine reduces shivering among patients after operations and decreases pain among children (Daviss W., Patel, N., Robb, A., McDermott M., Bukstein O., Pelham Jr W., Palumbo D., Harris P. et al 2008). There is no doubt that clonidine though leading to negative outcomes, it can be saving for the patients with a chronic pain. Clonidine produces sedative functions, as a rule. The researchers claim: “The use of intravenous clonidine infusions in critically ill children has been reported as safe and efficacious without occurrence of complication or need for intervention or support due to sedation, heart rate or blood pressure changes” (Vranken, van Kan, ven der Vegt 2006, p. 298). Another modern study conducted by Hildebrand, Elsberry and Hassenbusch (2003) is devoted specifically to analgesic qualities of clonidine. They were analyzed at the spinal level through stimulation of cholinergic interneurons in the spinal cord. In spite of usage of clonidine in the form of injections, there were conflicting results in this study. Clonidine evoked the neuropathic pain relieving action of NMDA antagonist MK–801, but there were no neurotoxic side effects. With respect to the current researches and studies it was found out that the main emphasis in the modern medicine is focused on combinatory approaches to pain treatment. On the example of 25 ...
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