This essay "Medications for treatment of obesity" outlines the remedies for obesity, their advantages, and disadvantages. Sibutramine
Sibutramine came in the market firstly as an antidepressant but because of its reduced efficacy for depression it was rather used for weight loss. It is a beta phenethylamine with a cyclobutyl group on its side chain. The mechanism of action of Sibutramine primarily revolves around the increase of satiety in an individual. It acts by inhibiting the release of three major neurotransmitters serotonin, norepinephrine and dopamine. It also acts by increasing the metabolism of the body which further increases the energy expenditures and thus helps a person to lose weight. While the person reduces his weight the metabolism of the body is still not reduced because of the activity of Sibutramine. Sibutramine has a role to play in nutrient drug interaction as it increases the metabolism of the body. It is necessary that the drug is prescribed with a regular balanced diet so that the satiety of the person is satisfied. Its side effects include increased blood pressure, dry mouth, insomnia and headache (Foster & Nonas 2004; Poston & Foreyt 2004).
Orlistat is also a drug prescribed for patients who are suffering from obesity. Orlistat is a derivative of lipstatin which acts differently than Sibutramine. Their primary mechanism of action is to lower the amount of calories absorbed from the gut. Orlistat inhibits the action of pancreatic lipases so that the fats cannot be digested and absorbed.
This helps in reducing the caloric intake of an obese individual. It works in a dose dependent manner which determines as to how much fat would be absorbed from the intestine. The effect of orlistat is such that after having a meal with high content of fat the patient usually has steatorheal diarrhea. But this diarrhea cannot prove to be fatal for the patient. The patients on orlistat usually have a deficiency of fat soluble vitamins as they cannot be absorbed from