StudentShare solutions
Triangle menu

The Stability of Tamoxifen - Essay Example

Free
2.4.1. Although it is not harmful to increase this quantity of glycerol, however the final formulation should not become too thick to process. 2.4.2. If this quantity is decreased, then for the relative increase in the quantity of water, it should be noted that the Tamoxifen Citrate would still dissolve considerably. 2.5. Hence, It is recommended that the glycol component should consist of about 10% by weight of propylene glycol and about 40% to 50% by weight of glycerol, in order to ensure the stability of Tamoxifen. 2.3. Research also suggests that for the formulation of Tamoxifen at highest stability so that the suspension of a fairly high percentage of Tamoxifen Citrate is made possible and simplicity of processing is maintained, the most favored formulation is a solvent mixture that consists of 15% by weight of ethanol, 10% by weight of propylene glycol, 50% by weight of glycerol, and 20% by weight of a sorbitol solution. The rest is the water. Such a formulation is stable enough to present a physically and chemically stable solution of Tamoxifen Citrate possessing the required amount of absorption. 3. Stability of Tamoxifen till its Release to the Market 3.1. To ensure the stability of Tamoxifen till its release to the market, the concept of nanoencapsulation has been implemented in the course of its strong ultrasonication and concurrent chronological polyelectrolyte deposition. 3.1.1. This is a fresh advancement that changes the thickness of the wall of the capsule so that the drug

Check these samples - they also fit your topic

Container Shipping and Chinese Stability
Container-based shipping ‘made the world smaller and the world economy bigger’ (Desrochers, Pierre, 2007). This quote explains the essence of the container-based shipping industry convenience. The most known advantages of this industry are the following: reduction of transportation costs and time; reliability enhancement; a decrease of theft.
9 pages (2250 words) Essay
Artificial Insemination Restrictions Based on Financial Stability
The procedure is, however, extremely costly, and only those with economic capabilities can afford. The procedure has provided infertile women with an opportunity to conceive children. Those who engage in this procedure often get in touch with their moral values and make their own decision.
8 pages (2000 words) Essay
Competition and financial stability
Many a banking sector has been stricken by banking crises for the past decades due to worldwide financial crisis. Although world wars impacted the banking system, the 21st century has thus far been more stable. The increased competition in the monetary markets has been among the main debating issues over the financial volatility across the globe.
8 pages (2000 words) Essay
COMPETITION AND FINANCIAL STABILITY
The view of competition fragility makes the argument on a negative relationship between financial stability and bank competition while the view of competition stability makes a positive relationship argument (Boyd et al., 2009: 4). Many studies have tested the relationship in different regions and nations and have come up with contrasting results.
8 pages (2000 words) Essay
Structural Stability Statement Essay
Although the bridge has a steel deck, the pylon is composite element, with an external steel formwork structurally connected to the filling concrete. The uniqueness of this bridge lies in sophisticated and complex design and construction stages and its unique manner of structural behaviour and load transfer, which makes it a structure only of its kind in the world.
5 pages (1250 words) Essay
International Finance - financial stability
The paper details its relevance in the global economy. It also analyzes and details factors that influence, and factors that articulate around international finance. To explain International finance it is the study pertaining to the dynamics of exchange rates, foreign investment, trade deficits, capital inflows, and how these affect international trade.
4 pages (1000 words) Essay
Corporate Strategy of Business/Companies
Understanding the process by which existing business/companies become obsolete and new business/companies evolve is what we are likely to discuss so that we can decide in which direction companies may change strategically to grow and perform. Strategy is the direction and scope of an organization over the long term, which achieves advantage for the organization through its configuration of resources within a changing environment and to fulfill stakeholders' expectations.
13 pages (3250 words) Essay
Structural Stability Statement
Designed by engineer Gustav Eiffel, the tower is an assembly of various wrought iron members which are put together with the help of rivets. The form notably tapers as the tower moves away from the ground. The structure consists of two visibly distinct parts: a base composed of a platform resting on four separate supports (called pylons or bents) it is a sort of bar stool, very sturdy, standing on 4 main pillars that are bonded and extended with a much lighter batter at the smaller level that constitutes the second floor, above this, a slender tower created as the bents taper upward, rising above a second platform to merge in a unified column.
6 pages (1500 words) Essay
Pharmacy - title : The stability of tamoxifen
The compound that is available normally is found as the meta stable polymorph. When Tamoxifen is crystalized from protic solvents, it starts forming crystals of the stable polymorph which shows disagreeable properties which results in yet additional
3 pages (750 words) Essay
Flight Stability
Sensitive control systems have been designed in aeroplanes to facilitate tight motion sensor systems that aid detection and correction of
7 pages (1750 words) Essay
release rate is adjusted and an antibody “at the outer shell layer for targeted delivery” is attached (Ochre Media 2010). 3.2. Another efficient method is to produce stable nanocolloids of Tamoxifen capsules which should have high substance of...
The Stability of Tamoxifen

There are two polymorphic forms of Tamoxifen’s crystals. The compound that is available normally is found as the meta stable polymorph. When Tamoxifen is crystalized from protic solvents, it starts forming crystals of the stable polymorph which shows disagreeable properties which results in yet additional insolubility of Tamoxifen in water. Thus, it remains stable. These detrimental properties of Tamoxifen influence its absorption performance in vivo which causes a reduction in its bioavailability. Tamoxifen’s polymorphic forms prevent the formulation of Tamoxifen Citrate as a suspension thus maintaining its stability during formulation. Because of the low intrinsic solubility of Tamoxifen’s molecule, even a little quantity that penetrates the aqueous solution leaves it soon enough, forming crystals of the unwanted polymorphic form. Hence, this level of stability of Tamoxifen during its formulation leads to the necessity of a “liquid formulation of Tamoxifen Citrate where crystallisation will not occur”.

After the primary polycation layer is deposited on the nanoparticle, an oppositely charged polyanion is added to it which forms a stable inter-polyelectrolyte complex shell around every drug nanoparticle. The final outermost layer is that of a polymer containing reactive groups like amino groups. It attaches ligands and desirable moieties to the surface of drug nanoparticles. This is how the Tamoxifen is stabilized till its release to the market.
Cite this document
  • APA
  • MLA
  • CHICAGO
(“The Stability of Tamoxifen Essay Example | Topics and Well Written Essays - 750 words”, n.d.)
Retrieved from https://studentshare.net/health-sciences-medicine/23519-the-stability-of-tamoxifen
(The Stability of Tamoxifen Essay Example | Topics and Well Written Essays - 750 Words)
https://studentshare.net/health-sciences-medicine/23519-the-stability-of-tamoxifen.
“The Stability of Tamoxifen Essay Example | Topics and Well Written Essays - 750 Words”, n.d. https://studentshare.net/health-sciences-medicine/23519-the-stability-of-tamoxifen.
  • Cited: 0 times

Summary

Tamoxifen is a well-known medicinal product which was developed in 1960. It is used to treat breast cancer, infertility, bipolar disorder, and gynaecomastia. Its other names are Nolvadex, Istabul and Voladex…
The Stability of Tamoxifen
Read Text Preview
Comments (0)
Click to create a comment
Let us find you another Essay on topic The Stability of Tamoxifen for FREE!
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us