genetic variation, especially presence of certain common SNPs, can cause variation in dietary response: e.g.: polymorphisms causing variance in levels of serum cholesterol and blood pressure can cause variance in dietary response (Artemis P. Simopolous, 2002, Genetic Variation and Dietary Response: Nutrigenetics/Nutrigenomics), and
dietary nutrients, as chemicals and as primary environmental factors that influence evolution, influence gene expression: e.g.: polyunsaturated fatty acids suppress fatty acid synthase (mRNA) gene expression (Artemis P. Simopolous, 2002, Genetic Variation and Dietary Response: Nutrigenetics/Nutrigenomics).
Dietary intake, by influencing gene expression, can become the associative cause of certain chronic diseases like atherosclerosis, diabetes, obesity, cancer, and others (Nutritional genomics: the next frontier in the post-genomic era, Jim Kaput and Raymond L. Rodriguez, 2003).
The first definition of nutrigenomics this research paper starts out with presents the science as being more effective for interactions of the first kind - genetic variation affecting dietary response - but in the light of the primary objective of this paper which is to maintain that nutrigenomics can be effective as a means to preventing, mitigating and curing a chronic disease - type 2 diabetes - the following definition, ...