Masters
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Health Sciences & Medicine
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This review addresses the topic of pharmacogenomics and the debate surrounding the prospects of using genetic screening to reduce the incidence of adverse drug reactions in patients on long-term drug therapy. …

Introduction

Finally, issues that surround the prospects of generalized genetic screening will be discussed in terms of the inherent advantages and disadvantages.An adverse drug reaction is defined as a negative and unintended consequence of taking a drug. These consequences are of two possible kinds: those resulting from an unwanted extension of the therapeutic action of the drug, and those unrelated to the therapeutic action of the drug. An example of the former would be daytime drowsiness caused by taking a tranquilizer at bedtime, while the latter may be exemplified by dry mouth caused by an antihistamine taken for allergy control. As will be shown later, both kinds of ADRs can be influenced by the genetic makeup of individual patients. Preventing ADRs is a crucial issue for patient drug treatment because a significant proportion of health care expenditure and time go into the management of conditions directly attributed to the ADRs caused by previous drug treatment (Beijer & Blaey, 2002; Moore, Lecointre, Noblet, & Mabille, 1998). ...
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