This essay An Examination of the Selectivity of Antagonist Drugs talks that to better understand the full implications of the interpretations of the results of this practical it is first deemed necessary to define a few important concepts dealt with herein. …
According to the research findings the ability of a drug to bind to a particular receptor on a cellular environment is determined by the chemical structure of the drug that allows it to interact with complementary surfaces on the receptor.
This paper declares that antagonists also bind to receptors but they do not have the ability of agonists to initiate changes in cellular functions. Instead, their prime characteristics are that they tend to occupy receptor surfaces thereby blocking agonist bindings on the same surface. This diminishes or even totally inhibits agonist functions that initiate changes in cellular functions. That is why they are termed as antagonists or blockers. There are two kinds of antagonists: competitive and irreversible. Competitive antagonists bind reversibly with receptors and high dosage of agonists may displace them and reinstate agonist interaction. On the other hand, irreversible antagonists bind irreversibly with receptors and do not allow displacement with increasing dosage of agonists. Treatment with Acetylcholine alone in increasingly concentrated dosages will increase response times to a certain dosage concentration. Thereafter, any increase in concentration will not elicit any significant increase in response time. One segment of tissue is treated with acetylcholine at FBC 1 micromolar strength. Two separate segments of the ileum tissue are treated with atropine and diphenhydramine respectively, both at FBCs of 3 micromolar strength, before being treated with acetylcholine at FBC 1 micromolar strength. ...
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Leadership Examination. Leadership Strengths and Weaknesses. Understanding the key strengths and weaknesses have been cited as the first major steps towards leveraging them ensuring that the strengths are fully utilized while the weaknesses as supported in order to achieve a goal (Northouse, 2010).
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