Postmenopausal osteoporosis is characterized by low bone mass with architectural deterioration of bone tissue resulting in increased bone fragility. Logically, one can derive that postmenopausal osteoporosis that follows ovarian failure is a result of acceleration of bone resorption due to enhanced osteoclast function . Osteoclasts (OC) are related to macrophage family of cells, hence osteoclasts are regulated by same family of cytokines, such as, tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1), and these mediate the bone resorptive function of OC. Investigating the fact that oophorectomized prematurely menopausal women have enhanced bone loss, it has been established that estrogen deprivation enhances the production of proresorptive cytokines, IL-1 and TNF- α in excess in menopausal women , and those lead to a hormone-dependent increase in bone resorption and resultant accelerated loss of bone mass in the first 5 to 10 years of menopause. As regards to bone density outcomes, many randomized controlled trials have shown consistently identical improved bone density with estrogen use; consequently, it was postulated that estrogen does this by reducing the production of catabolic cytokines by osteoclasts and mononuclear phagocytes. Hence it could be concluded that neutralization of TNF-α and IL-1 protects against estrogen deficiency bone loss.
Cite this document
(“A Comparison between the Mechanisms of Action of Hormone Replacement Essay”, n.d.)
Retrieved from https://studentshare.net/health-sciences-medicine/329309-a-comparison-between-the-mechanisms-of-action-of-hormone-replacement-therapy-and-selective-estrogen-receptor-modulators-in-the-treatment-of-postmenopausal-osteoporosis
(A Comparison Between the Mechanisms of Action of Hormone Replacement Essay)
“A Comparison Between the Mechanisms of Action of Hormone Replacement Essay”, n.d. https://studentshare.net/health-sciences-medicine/329309-a-comparison-between-the-mechanisms-of-action-of-hormone-replacement-therapy-and-selective-estrogen-receptor-modulators-in-the-treatment-of-postmenopausal-osteoporosis.
Cited: 0 times
The sex steroid hormone estrogen is important for various physiologic processes, such as, bone remodeling; breast ductal tissue proliferation; and growth, differentiation, and function of reproductive system among others…
Thanks to unconventional medical procedures, altering one’s innate characteristics, viz., gender, genetic makeup, physical appearances, etc., is not impossible anymore. One of the most significant advances of medical sciences is in the field of Hormonal Replacement Therapy (HRT).
Under normal conditions, the bone is comprised of protein collagen and calcium ("MedicineNet"). For a healthy adult, bone is continually absorbed by and rebuilt into the body. Bones become larger and heavier as new bone tissue is added faster that existing bone is absorbed.
Teras, Michael J. Thun, and Eugenia E. Calle, Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta Georgia, Weight Gain, Body Mass Index, Hormone Replacement Therapy, and Postmenopausal Breast Cancer in a Large Prospective Study
While the existence of hormone replacement therapy provided the cure for dwarfism, the most common result of a deficiency of somatotropin, it has also given an insight into the effects of the human growth hormone in the process of aging.
A study focusing on the levels of growth hormone in relation with age was performed Russell-Aulet et al.
is given to some clients, HGH can promote growth and fight some of the effects of aging; on the other hand, it is not as useful the older the person taking it is, and there are other limiting factors. “Growth hormone is clearly our master hormone because of its ability to
Experts have specified that number of older people suffering from osteoporosis will continue to increase with increment in world population. Eighty percent of abovementioned sufferers are women, and particularly women older than fifty years of age. Besides different risk factors, ethnicity plays a significant role in the development of osteoporosis.
These therapies are used to add, block or remove hormones. There is controversy on this topic because it has several health risks associated with it but it also has the potential to help people who are oncology patients. Also, the issue of sexual reassignment and its ethical value is also controversial.
the treatment can also be done on aging for example hormone replacement therapy (menopause), testosterone replacement in males with low levels due to disease or aging. Another area where hormonal therapy is used is on sex reassignment for instance; hormonal replacement therapy
One of the things that can account for the fact that the white progressives of early 20th Century favored policies rooted in racist ideas is the fact that their prohibition for child labor did not cater for the Italian children who were recruited by their parents in the guise of helping them with homework.
The author states that the advantages of hormone therapy are dictated by the mode of administering the medicines: whether it is systemic or low-dose use of estrogen. On the one hand, systemic hormone therapy pills containing estrogen, balm or spray, and skin patch continues to be the most appropriate treatment for symptomatic hot flashes.
4 pages (1000 words)Essay
Got a tricky question? Receive an answer from students like you!Try us!
Let us find you another Essay on topic A Comparison between the Mechanisms of Action of Hormone Replacement Therapy and Selective Estrogen Receptor Modulators in the Treatment of Postmenopausal Osteoporosis for FREE!