Furthermore the report also covers the spectrophotometric analysis to determine the preservative actions of benzoic acid, methyl parabens and propyl parabens and also the supportive action of propylene glycol as a preservative. Finally better methods are suggested to negate and minimize the random and systemic errors during the experiment in order to achieve the best possible stabilized emulsion. Keywords: Hydrophile-lipophile Balance, Span 80, Tween 80, Spectrophotometric analysis, propylene glycol PART - I INTRODUCTION An emulsion is a setup of two immiscible liquid phases with one of them dispersed throughout the other in form of tiny and fine droplets. The phase consisting of tiny droplets is defined as the internal or disperse phase whereas the suspension phase is classified as the external or continuous phase. Water and oil are the two major constituents of pharmaceutical emulsions. An aqueous continuous phase will render the emulsion as oil-in-water (o/w) whereas an oily continuous phase will make a water-in-oil (w/o) emulsion. The stability of an emulsion is dependent on the characteristics of the interfacial film. Addition of an emulsifying agent lowers the interfacial tension and increases the stability of the emulsion. A wide variety of these substances are available: e.g. egg yolk, cetearyl alcohol, polysorbate 20, ceteareth 20 etc. In the past emulsions have been used to impart paraffin oil and other oily substances in a more palatable form (Aulton 1988, p. 93). Nowadays emulsions are very common in foods, cosmetics, personal hygiene and especially pharmaceuticals. Creams, ointments, liniments, pastes and films are some examples of pharmaceutical emulsions. They are classified according to the oil and water content in each of the preparation and also on their routes of administration (Troy, Remington & Beringer 2006, p. 886-887). To achieve the production of a stabilized emulsion this experimented was conducted in order to formulate a scientific method of emulsion design. MATERIALS & METHOD A condensed film consisting of an oil soluble component (OSC) and a water soluble component (WSC) in a ratio of 9:1 for the required o/w emulsion is needed at the interface between oil and water in order to achieve the best result. The Hydrophile – liphophile balance method (HLB) was designed in order to calculate the perfect HLB requirement of the oil. According to the method, a HLB number is allotted to each and every surfactant depending upon the extent of hydrophilicity and lipophilicity of the molecule. A surfactant expressing only hydrophilic properties is given the maximum number of 20, with sodium lauryl sulphate being the only exception having a HLB number of 40. MATERIALS Liquid Paraffin, Tween 80 (polyoxyethylene 20 sorbitan mono-oleate, Span 80 (sorbitan mono-oleate) Span 80 is selected as the OSC while Tween 80 is selected as the WSC at total blend concentration of 2% w/v. Both compartments are then administered into screw capped sample vials via a burette and then labeled. The vials are agitated by inversion and then emulsified by drawing into and expelling from a syringe three times. Six different formulations were prepared with varying ratios of Span 80 and Tween 80. The HLB of each formulation was calculated from the equation given below, so as to determine the required HLB of the oil. HLB [formula] = f [OSC] . HLB [OSC] + (1-f) [WSC] . HLB [WSC] The vials were left for 15 minutes and their stability was observed in
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EMULSION TECHNOLOGY by Name of of Class Name of Professor Name of University Name of City Date PART I + PART II ABSTRACT This lab report explores the idea of designing a formulation of a stabilized emulsion and identifying the best preservative for the preservation of an emulsion…
The water in oil (w/o) emulsion has the HLB value well with in the detergent limit. The emulsion is prevented from breaking by reducing the surface tension of the film. By the combination of two emulsifiers with big difference in HLB values, the film is strengthened.
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1 pages (250 words)Lab Report
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