Children with Asthma Who Take Budesonide and Who Take Nedocromil - Research Paper Example

Children with Asthma Who Take Budesonide and Who Take Nedocromil Objective: To ascertain whether children with asthma who take budesonide experience reduced severity of attacks compared to those who take nedocromil. Modern research pertaining to the disease have found that impaired growth of lungs during childhood together with gradual decline in pulmonary function are a major cause of asthma in adulthood. Consequently, clinicians have suggested that the use of anti-inflammatory medication for a long period of time can be used to control recurrent asthmatic attacks. Such medications include corticosteroids or nedocromil inhalants for children. Methods: This study employed the use of tertiary data gotten from past literature analysis that relate to the topic in question. In line with the topic of discussion, the search for relevant literary material focused on several databases including New England Journal of Medicine, Respiratory Medication and more. Key words like "asthma" " budesonide " and " nedocromil" were used in order to find precise articles. Discussion: In as much as different studies show that children with asthma who take budesonide experience reduced severity of attacks compared to those who take nedocromil, more and proven evidence is needed to likewise show that nedocromil medication can also have positive effects on children with incessant asthma attacks. Conclusion: Children with asthma who take budesonide experience reduced severity of attacks compared to those who take nedocromil. Introduction The treatment of asthma in children by physicians should be so effective that its end result is a child growing with near-perfect life devoid of constant chest and breathing complications. This means that physicians have to employ top-notch medical practices and procedures to ensure that this objective is achieved. Due to the fact that there has never been comparative analysis between the efficacy of nedocromil sodium and inhaled corticosteroids in treating childhood asthma, it is not possible to discern their comparative usefulness.5 Thus, the need for broadened research in this area cannot be neglected. Importantly, it is necessary to discuss the relevant terms used in this study. Key words that have been used in this study include; sodium cromoglicate and budesonide. To begin with, sodium cromoglicate is a type of asthma inhalant that is used regularly by asthma patients to prevent potential attacks. However, it does not help in cases where an asthma attack that has already started.2,4 On the other hand, budesonide is an inhalant used to prevent asthmatic attacks. Studies have shown that if used regularly budesonide decreases the symptoms and severity of asthma attacks. It does not however, relieve asthma attacks that have already started. Methods In line with the topic, the paper utilized various databases like Google Scholar, Bing, Yahoo and many more to find relevant articles. Similarly, websites containing medical journals were accessed and important articles used in this study retrieved. Such journals include PubMed, New England Journal of Medicine, British medical journal et cetera. Another method used to get associated articles was through discrimination by year of publication whereby articles with the most updated time frame were picked. For example, most articles considered for this paper were written between 2007 and 2017. Similarly, the use of key words while searching for articles helped to get precise articles needed. Besides using common words pertaining to the study like asthma, anti-inflammatory, budesonide and many more, the search terms were expanded to include combination of words like “benefits of budesonide” “treating asthma in children” Discussion Save for two articles used in the study, the rest of the articles incorporated at least two of the known Clinical study designs. The first article in this case is from the Acad Emerg Med journal. According to the researchers, the article employed a single study design based on the open-trial method since other designs were not applicable at the time the children were studied. The study was done by discontinuing the use of cromolyn sodium therapy at the initial stages and using budesonide therapy instead. Similarly, terbutaline and theophylline were allowed except prednisone. At the second year of follow-up, the researchers noted that an acute exacerbation of asthma was managed by the above treatment procedure.1 The results showed that as compared with the control method of asthma before budesonide therapy was adopted, there was improvement in control one month after the new method was initiated. Clearly, the study proved that long-term usage of budesonide inhalants was efficient in reducing asthma severity despite the study taking an uncontrolled approach. Similarly, the study shows that usage of budesonide therapy did not affect growth and pituitary-adrenal function in children. The second article that adopts a single study design approach is Effect of inhaled glucocorticoids in childhood on adult height journal. The article used prospective, long-term study approach. In this case, Children with asthma were recruited for a prospective, long-term study. Those with other serious illnesses or with a gestational age of less than 32 weeks were excluded from the study. Three hundred thirty-two children with controlled asthma and without continuous use of inhaled corticosteroids were asked to change treatment with the inhaled corticosteroid budesonide.2 The change in therapy was accepted by families of 270 children (the budesonide group) while families of 62 children declined to change citing various concerns. The study found that children with asthma who had continuously used inhaled budesonide attained normal adult height. The researchers noticed that long-term treatment with inhaled budesonide did not have adverse effects on adult height. The rest of the articles adopted more than one study design. The first article to consider in this category is the Evaluation of efficacy and safety of budesonide delivered via two dry powder inhalers article. The researchers randomly assigned three hundred eleven children to budesonide therapy as another 208 were assigned to receive a matching placebo. Three hundred twelve children were also assigned to nedocromil sodium treatment and whereas another 210 were assigned to receive a matching placebo. At the end of the study, the researchers noticed that unlike the placebo group, the budesonide group had a reduced rate of hospitalization cases approximated to 43 percent (P=0.04) and a 45 percent lower rate of emergency care (P Read More