Traditionally synthetic morphinomemetics have severe toxic side effects which rarely can become fatal. Hypotension is a characteristic of these drugs in addition to liver cirrhosis(because of high levels of toxicity) and urinary retention.Pain-free was regarded as promising because it had some advantages over other brands of morphinomimetics, namely;liver problem was considerably managed, no sign of tetramoraide syndrome was found and it’s effectiveness in obliterating pain was instant and exceptional, though hypotension could not be dealt with(and this was not conveyed to the consumers aka patients). In1993, 17% of the patients showed signs of orthostatic hypotension.1 Evidence suggested that Normoramide was the cause. A team led by Roland Peterson had worked tirelessly at eradicating the fatal liver problem but during the course of improving the drug, it was established that hypotension could not be dealt with. Pain-free indisputably was a significant breakthrough especially considering the miraculous pain relief it provided, and appeared to be potential ‘commercial blockbuster’. However, orthostatic hypertension could not be obliterated (as it was conveyed to the prospect consumers) and to this extent, it can be alleged that the company misled the consumers. In addition, the ‘innovation’ in the drug becomes questionable. The management omitted some very pertinent facts about the drug, which if they were known would have affected consumption decision of the patients. The instances of non-disclosure can be enumerated as follows. a) In 93, out of the patients tested with the drug 17% exhibited hypotension.2 The management sought an alteration of guidelines and after it was affected, these cases were written off as ‘occurrences prior to alteration” thus were disregarded.
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An author of thr essay "The Implication of Theories of Activity for Management of Operation" reports that it was basically a non-addictive analgesic drug which could be taken orally and helped in reducing post-operative, rheumatologic pain and migraines…
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