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Diet Effects on Plasma Lipoproteins - Essay Example

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Diet Effects on Plasma Lipoproteins

It is in the form of lipoprotines that the cholesterol and triacylglicerol are set on the move in blood. Ordovas (2005) has characterised lipoproteins as "generally spherical particles, with a surface layer composed of phospholipids with the fatty acids oriented toward the core of the Particle". Carrying lipids from one inner organ to another is being the main function of these lipoproteins. The lipoproteins are chiefly those chylomicrons, named Very low-density lipoprotein (VLDL), Immediate-density lipoprotein (IDL), Low-density lipoprotein (LDL), High-density lipoprotein (HDL).
Chylomicrons are the largest lipoproteins, consisting mainly of triacylglycerol with apoB-48 and apoA, -C, and -E. Triacylglycerol is hydrolysed with endothelial-bound lipoprotein lipase, changing the chylomicron into a chylomicron remnant rich in cholesteryl ester. These remnants are removed from the circulation by interaction with the remnant receptors mainly present on hepatocytes.
Chylomicron remnant rich in cholesteryl ester is made from chylomicron when triacylglycerol is hydrolysed with lipoprotein lipase that move towards endothelial. Mainly by the contact with remnant receptors found mostly on hepatocytes, the chylomicron remnants are removed. Tryacylglycerol with apoB-48, and apoA, -C, and -E are present in chylomicrons which are the major lipoproteins.
Very low-density lipoproteins are secreted mainly by the liver, with apoB-100...
VLDL particles vary in size. Small VLDL is converted into LDL, via IDL, to a greater extent than large VLDL, which is converted to a form of IDL that appears to be removed from the plasma before conversion to LDL.
Mostly, liver discharges very low-density lipoproteins with an exterior of apoB-100 and apoE. Then, they build up with apoC, and apoE from HDLs and turn into mature VLDLs. The particles of VLDL can be different in size. The chances of turning into LDL via IDL is greater for the smaller particles while, the larger VLDL particles transforms into a form of IDL seems only to be separated from the plasma without being turned into LDL. The HDLs come across the lipoprotein lipase to change themselves into IDLs which is either consumed back by the liver or get intermingled with the hepatic triglyceride lipase to be changed into LDL.
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Intermediate-density lipoproteins ( IDL ) are intermediate particles formed from the conversion of VLDL to LDL. Some are removed directly from plasma, whereas some convert into LDL.
Some particles of VLDV are separated from the plasma while it is being transformed into LDL. The midway (intermediate) particles formed during the translation of VLDL to LDL are the Intermediate-density lipoproteins (IDL).
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Low-density lipoproteins ( LDL ) are the major cholesterol-carrying particle in the plasma. The core is cholesterol ester and has one apolipoprotein, apoB-100, per LDL particle. There are different sizes of LDL. Approximately one-third of the intravascular pool is catabolised per day and three-fourths of the circulating LDL is cleared through the liver, mainly through the LDL receptor. Small, dense LDL is more common in some dyslipidemias and may be more easily oxidized than larger LDL. However, oxidized ...Show more

Summary

Cholesterol and triacylglycerol are transported in blood as lipoproteins. Ordovas ( 2005 ) defined lipoproteins "Lipoproteins are generally spherical particles, with a surface layer composed of phospholipid with the fatty acids oriented toward the core of the particle"…
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Diet Effects on Plasma Lipoproteins essay example
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