Diet Effects on Plasma Lipoproteins

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Cholesterol and triacylglycerol are transported in blood as lipoproteins. Ordovas ( 2005 ) defined lipoproteins "Lipoproteins are generally spherical particles, with a surface layer composed of phospholipid with the fatty acids oriented toward the core of the particle"…

Introduction


It is in the form of lipoprotines that the cholesterol and triacylglicerol are set on the move in blood. Ordovas (2005) has characterised lipoproteins as "generally spherical particles, with a surface layer composed of phospholipids with the fatty acids oriented toward the core of the Particle". Carrying lipids from one inner organ to another is being the main function of these lipoproteins. The lipoproteins are chiefly those chylomicrons, named Very low-density lipoprotein (VLDL), Immediate-density lipoprotein (IDL), Low-density lipoprotein (LDL), High-density lipoprotein (HDL).
Chylomicrons are the largest lipoproteins, consisting mainly of triacylglycerol with apoB-48 and apoA, -C, and -E. Triacylglycerol is hydrolysed with endothelial-bound lipoprotein lipase, changing the chylomicron into a chylomicron remnant rich in cholesteryl ester. These remnants are removed from the circulation by interaction with the remnant receptors mainly present on hepatocytes.
Chylomicron remnant rich in cholesteryl ester is made from chylomicron when triacylglycerol is hydrolysed with lipoprotein lipase that move towards endothelial. Mainly by the contact with remnant receptors found mostly on hepatocytes, the chylomicron remnants are removed. Tryacylglycerol with apoB-48, and apoA, -C, and -E are present in chylomicrons which are the major lipoproteins.
Very low-density lipoproteins are secreted mainly by the liver, with apoB-100 ...
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