Got a tricky question? Receive an answer from students like you! Try us!

Pharmacology question (Neostigmine) - Essay Example

Only on StudentShare
Author : camillerath


Centrally acting muscle relaxants: These drugs inhibit transmission in polyneuronal pathways controlling muscle tone. Thus, they inhibit spinal interneurones and promote inhibitory influences of the brain stem reticular formation on spinal motor neurones. They reduce spasm of skeletal muscles without affecting voluntary movement.

Extract of sample
Pharmacology question (Neostigmine)

Ach is rapidly inactivated by ChE and endplate returns to its resting potential. However, if there is prolonged depolarization induced by these drugs, there is no further generation of action potential after the initial twitch and there is loss of electrical excitability at the motor endplate.
Directly acting muscle relaxant: They exert direct action on the skeletal muscle, by interfering with the release of Ca2+ from the sarcoplasmic reticulum, they interfere with the excitation-contraction coupling (Bhattacharya 2003).
Treatment of respiratory paralysis arising from an adverse reaction or overdose of a neuromuscular blocking agent should be by positive pressure artificial respiration with oxygen and maintenance of a patient airway until the recovery of normal respiration is assured. With the competitive blocking agents, this may be hastened by the administration of neostigmine methyl sulphate (0.5 to 2mg, intravenously) or edrophonium (10mg intravenously, repeated as required.) (Hardman 1996).
Neostigmine is a quaternary ammonium compound that inhibits cholinesterase activity and thus prolongs and intensifies the physiological actions of acetylcholine. It probably also has direct effects on skeletal muscle fibres. ...
Download paper

Related Essays

scenario question
Related jurisprudence shall be discussed and analyzed; explications will be given to the end that the instant controversy would have a viable solution for the benefit of both parties and to the members of the global community as a whole.…
20 pages (5020 words)
Intelligence is a personal resource that helps a person to attain personal growth and adjustment into a learning environment. Intelligence is a shield against psychological stress and diseases.…
2 pages (502 words)
discussion question
Assuming there are 1 billion writers, is it not possible that there are exactly two the same sentences There have been some records indicating exactly look alike in images, what more with written lines when writing has been here since time immemorial Is not plagiarism a simple commerce hiding behind the facade of protecting the rights of others, while prejudicing the rights of some…
2 pages (502 words)
At this point, Mary was prescribed the corticosteroid known commercially as Advair. Initially, she was compliant with the recommended dose of two inhalations daily, but later began to forget. In her most recent clinic visit, this practitioner has diagnosed Mary with bacterial pneumonia following chest x-ray and isolated cultures from sputum samples. Cough was initially dry, but grew productive over the course of 24 hours. Spirometry was performed in which she achieved a forced expiratory volume of 62%. The chest x-ray revealed a flattened diaphragm, following this observation Mary was…
8 pages (2008 words)
Propranolol was found to reduce the blood pressure, cardiac output, and others in the cats, when administered intravenously (Aderg et al., 1969).…
5 pages (1255 words)
Activated tyrosine kinase in turn activates the signalling pathways such as protein kinase C pathway, Scaffolding proteins, Ras/Raf mitogen – activated protein kinase pathway, and phosphoinositol 3’ – kinase/Akt pathway (Arora and Scholar, 2005). These activated pathways alter the DNA synthesis along with cell growth, differentiation, and others.…
5 pages (1255 words)
In these tissues, CD243 helps protect the tissue from cytotoxic effects of toxins. Further still, P-gp promotes the excretion of drugs into the bile ducts of the liver, excretion of drugs into urine, and excretion of drugs into the capillaries of the BBB (Schinkel et al., 1995; Horn & Philip, 2004).…
5 pages (1255 words)