Alpha Lipoic Acid what is it, and how does it improve (help) peripheral neuropathy and insulin resistance

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Alpha lipoic acid (ALA) is a potent antioxidant and free-radical scavenger. It is both water and fat soluble and can regenerate endogenous antioxidants. ALA has been shown to both decrease blood sugar in diabetics as well as attenuate secondary conditions associated with diabetes.


The metabolic dysregulation associated with DM causes secondary pathophysiologic changes in multiple organ systems that impose a tremendous burden on the individual with diabetes and on the health care system. The two broad categories of DM are designated type 1 and type 2. ALA has been shown to be useful in type 2 diabetes mellitus, and in order to understand the mechanism of action of ALA in control of DM and DM-associated complicating conditions, such as, neuropathy, it is important to understand the pathophysiologic and biochemical mechanism of these conditions (Boulton, 2005).
A prominent biochemical feature of type 2 DM is insulin resistance. This group of disorders is characterised by a pathogenic process that leads to hyperglycemia through variable degrees of insulin resistance, impaired insulin secretion, and increased glucose production. Type 2 DM is characterized by three pathophysiologic abnormalities: impaired insulin secretion, increasing peripheral insulin resistance, and excessive hepatic glucose production. Obesity, particularly visceral or central as evidenced by the hip-waist ratio, is very common in type 2 DM. ...
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