StudentShare solutions
Triangle menu

Cachexia - Essay Example

Not dowloaded yet

Extract of sample
Cachexia

But in cachexia, the issue is that patients, regardless of the adequacy of nutritional intake, have abnormally accelerated disposition of nutrients, hence a negative balance of metabolism results (Fearon and Moses, 2002). Inflammatory processes are involved in secondary PEM which are absent in primary PEM, and while primary PEM can be reversed by bolstering nutrient intake, the same benefit cannot be obtained in secondary PEM. In primary PEM there is faster loss of adipose tissue than that of lean body mass, but the loss is equally from both compartments in cachexia. Skeletal muscle loss is a feature that is peculiar to the cachexic state (Tisdale, 2003).
Previous laboratory and clinical studies have shown that omega-3 fatty acids, especially eicosapentaenoic acid (EPA) and EPA-containing supplements demonstrate molecular anti-inflammatory activity which is relevant to the attenuation of cachexia, in both humans and animal models. However, past results from multiple studies have been equivocal in their findings, and this study aims to elicit independent objective evidence in favour of or against the proposition that EPA confers significant benefit in arresting the progress of cachexia in affected patients.

Question 5
Yes. There was inadequate discussion of the basis for their using the type of EPA preparations they used, as opposed to other available types. The authors could also have done a better job of reviewing the literature on the mechanistic aspects of how cachexia develops and what bearing this information will have on the approach they used for their study in terms of study design, formulations used and patient selection strategies.

Question 6
These patients have undergone treatment procedures that are potentially debilitating and could contribute directly or indirectly to changes in body mass or global physical status. Such changes may confound the results of the study. It is standard practice in conducting clinical trials to exclude patients who have such conditions as could independently contribute (whether negatively or positively) to the observed end points, otherwise type 1 (false positive) or type II (false negative) errors may result during the interpretation of the results.

Question 7
C-reactive protein (CRP) measurement is being used as a marker of the severity of the acute inflammatory protein response which occurs in cachexia. CRP is an acute phase protein whose synthesis is induced in cachexia by interleukin-6 and tumor necrosis factor alpha, and its level has been correlated with severity of symptoms and adverse outcomes (Tisdale, 2003).

Question 8
Only half of the original population enrolled completed the 8-week course of the trial, although this was attributed to miscellaneous reasons not linked to lack of compliance or adverse effects from the EPA preparations.
For mean weight change over the 8-week period, the group ...Show more

Summary

Cachexia is described as a medical state with characteristic symptoms which manifest as metabolic abnormalities along three lines: relative hypermetabolism, which describes an abnormally high rate of catabolic activity which creates a negative metabolic balance, even in the presence of adequate nutritional intake; acute-phase protein response refers to a cascade of inflammatory processes mediated by protein-type inflammatory biochemicals in response to insult from cancer; and a failure of anabolism compounded by inadequate food intake, which means that the ability to assimilate nutrients for body-building is being compromised at the same time that the underlying disease is causing diminished …
Author : hicklelaney
Cachexia essay example
Read Text Preview
Save Your Time for More Important Things
Let us write or edit the essay on your topic
"Cachexia"
with a personal 20% discount.
Grab the best paper

Related Essays

Legalization of Marijuana
The evidence clearly shows that legalizing marijuana for general use and medicinal purposes would be advantageous for society, evidence which is recognized throughout the scientific, public and political realms but this well-known and widely acknowledged evidence has not yet to be acted on in the U.S.
4 pages (1000 words) Essay
Benefits of medicinal marijuana
It would free up funds and law-enforcement manpower to instead combat the more urgent societal issues.Although not legal in the Netherlands,cannabis is openly tolerated and can be both purchased and consumed in one of several Amsterdam ‘coffee houses.’
5 pages (1250 words) Essay
Disscuss the Differential Diagnosis and Underlying Pathologies for a 60 Year Old Male
Discuss referral options. The subject under discussion for differential diagnosis is a 60 year old male who is complaining of weight loss, shortness of breath and a persistent cough with traces of blood in his sputum or haemoptysis. Cough, shortness of breath and sputum production is mainly the symptom of the respiratory system.
5 pages (1250 words) Essay
Medical Marijuana Essay
Ten years down the line, the same newspaper, wrote yet another article invalidating its campaign for marijuana decriminalization due to the increasing evidence that the use of marijuana is far from harmless. Marijuana, otherwise known as cannabis, happens to be the most extensively used illegal drug in a number of developed countries.
5 pages (1250 words) Essay
Critical Analysison a study-Cancer cachexia- omega 3 benefits
nce of adequate nutritional intake; acute-phase protein response refers to a cascade of inflammatory processes mediated by protein-type inflammatory biochemicals in response to insult from cancer; and a failure of anabolism compounded by inadequate food intake, which means that
8 pages (2000 words) Essay
Colon Cancer In Men
The most common predisposing condition leading to adenocarcinoma is adenomatous polyps. Alterations in the adenomatous polyposis or APC gene as a result of mutations is the beginning point of development of the cancer.
4 pages (1000 words) Essay
A 5 page Casual Argument essay on the use of medical marijuana
It would free up funds and law-enforcement manpower to instead combat the more urgent societal issues. Although not legal in the
5 pages (1250 words) Essay
In support of the legalization of marijuana for medical use
Those in support have established reasons for marijuana legalization particularly in the medical field. Many have established the need for legalization based on past records when the drug was used as natural remedy to
5 pages (1250 words) Essay
Part 1 Final Exam essay format
Antioxidants are found in abundance in cruciferous vegetables like broccoli, cauliflower, kale, Brussels sprouts and cabbage that assist in reducing the risk of prostate and other
3 pages (750 words) Essay
Approach to care
When the normal cells become cancer cells, that part of the body becomes cancerous. The cells grow in a methodical manner and generate more cells to maintain the health of the body. The genetic material (DNA) of a cell gets damaged, which results in
5 pages (1250 words) Essay
Get a custom paper written
by a pro under your requirements!
Win a special DISCOUNT!
Put in your e-mail and click the button with your lucky finger
Your email
YOUR PRIZE:
Apply my DISCOUNT
Comments (0)
Rate this paper:
Thank you! Your comment has been sent and will be posted after moderation