Moreover, it may also send confusing messages to girls that premarital sex is acceptable. Consequent high risk behavior in young girls may ultimately lead to fatal carelessness by acquiring HIV infection.
Another concern which remains is that Gardasil is only protective against HPV strains 16, 18, 6 and 11, which account for 70% of all cervical cancers. As there are more than 80 serotypes, with several serotypes associated with high and intermediate risk of developing cervical cancer, protection against all of them remains elusive. Moreover, different HPV serotypes may be linked with cervical cancer in different regions of the world, resulting in marked differences in the protective efficacy of the vaccine. The highest risk relates to the safety of the vaccine, which has not been proven yet. Majority of the subjects who received Gardasil had side effects within 15 days, which included fatigue, muscle pain and inflammation at injection site (Merck's Gardasil vaccine not proven safe).
The current vaccines containing synthetic/ recombinant antigens are less immunogenic than the older versions of vaccines derived from live attenuated or killed organisms.