This study is an attempt to explore the possibility of obtaining a positive correlation with dose, effects and side effects of the drug using EEG recording so that a minimum and maximum dose range of the drug can be obtained for effective treatment of Schizophrenia.
Clozapine is a tricyclic dibenzodiazepine derivative 8-chloro-11- (4-methyl-1-piperazinyl)-5H-dibenzo [b, e] [1,4] diazepine. It is available as 25mg and 100 mg tablets for oral administration. Clozapine is widely used in refractory Schizophrenia. There seems to be a cultural and geographical variations in dose response relationship and tolerability to the drug making the dose response unpredictable. The effective and tolerable range is between 100 mg to 900 mg, which makes it difficult to make a predictive, significant and valid correlation. There has been no positive correlation with serum level too. Thus, there is a need to search for a clinically viable and simple method for growth response monitoring of the drug. The present study is an attempt to evolve such a method. Thus, the study focuses on the effect of clozapine on EEG pattern of the Schizophrenia. patients to explore the possibility of obtaining a positive correlation with dose, effects and side effects so that a minimum and maximum dose range of the drug can be obtained for effective treatment of Schizophrenia.
MATERIALS AND METHODS
The study was done in the year 2000 at a tertiary care center. This open level prospective cohort naturalistic study was done on patients selected randomly after informed consent.50 patients referred to clozapine therapy were studied for a period of three months. A conventional 10 channel EEG with international 10-20 system of montages was recorded during a fixed time of 5-7 PM at baseline, 4, 8 and 12 weeks.
RESULTS AND DISCUSSION
Any attempt on obtaining a correlation of EEG data with clozapine dose response should be substantiated by a review of current research findings on clozapine therapy associated EEG abnormalities to evaluate the relevance and significance of the recorded data. Electroencephalogram (EEG) slowing has been shown to be associated with clozapine side effects and can be used as a marker to predict treatment response during clozapine treatment.
(Wichniak A et.al, 2005). Patients with schizophrenia have been found to show N1, P3 and Late Slow Wave abnormalities indicating impairment in early stimulus evaluation and subsequent working memory functions. Subsequent treatment with clozapine seem to have induced normalization of the P3 and Late Slow Waves, indicating improvement in working memory updating and executive processing. There also seems to be a partial normalization of N1 amplitude, suggesting improvement in early stimulus evaluation. ( Galletly CA et.al ,2005). In patients treated with electro convulsive therapy along with parallel administration of antipsychotic