This study is an attempt to explore the possibility of obtaining a positive correlation with dose, effects and side effects of the drug using EEG recording so that a minimum and maximum dose range of the drug can be obtained for effective treatment of Schizophrenia.
Clozapine is a tricyclic dibenzodiazepine derivative 8-chloro-11- (4-methyl-1-piperazinyl)-5H-dibenzo [b, e] [1,4] diazepine. It is available as 25mg and 100 mg tablets for oral administration. Clozapine is widely used in refractory Schizophrenia. There seems to be a cultural and geographical variations in dose response relationship and tolerability to the drug making the dose response unpredictable. The effective and tolerable range is between 100 mg to 900 mg, which makes it difficult to make a predictive, significant and valid correlation. There has been no positive correlation with serum level too. Thus, there is a need to search for a clinically viable and simple method for growth response monitoring of the drug. The present study is an attempt to evolve such a method. Thus, the study focuses on the effect of clozapine on EEG pattern of the Schizophrenia. ...Show more