It was observed there is high aggregation of Fibromyalgia in families of Fibromyalgia patients. The mode of inheritance followed is probably polygenic. An association between Fibromyalgia and polymorphisms of the genes in the serotoninergic, dopaminergic and catecholaminergic systems was observed in research. However these polymorphisms are not specific for Fibromyalgia and are associated with a range of somatic disorders and with depression (Buskila 332-8).
Stress is often considered as a risk factor for Fibromyalgia It has also been hypothesized that because exposure to stressful conditions can alter the function of the hypothalamic-pituitary-adrenal (HPA) axis, the development of fibromyalgia may stem from stress-induced disruption of the HPA axis (McBeth et al . R992-R1000)
There is strong evidence that major depression and fibromyalgia are associated with each other. The symptoms of fatigue, sleep disturbances, and cognitive disturbances that are characteristic of Fibromyalgia are also present in depressive illness. Patients with Fibromyalgia often improve with antidepressant medications. Although current major depression was found in only about 18-36% of Fibromyalgia patients, a lifetime history of depression was observed in 50-70% of the cases in a study (Goldenberg 778-779). ...Show more