Understanding of the nature of major challenges associated with the ageing population is becoming an increasingly critical aspect of modern health care system.
A considerable body of evidence is now available to show that the process of aging is largely due to molecular damage caused by reactive oxygen species, electrophiles, and other reactive endobiotic and xenobiotic metabolites (McEwen et al. 2005). Ageing is associated with the degeneration of functional capacity in all parts of human body, and at all levels of organisation from molecules to complete organ systems. This process is normally referred to as 'senescence' and comprises genetic and external factors (Mera 1992).
Quality of life of elderly patients depends more on ageing-related disease than solely on chronological characteristics. ...Show more