I will address an important topic that still causes major morbidity and mortality around the world, especially in low income populations and children.
2. Iron-deficient erythropoiesis: after iron stores are exhausted, lack of iron limits the production of hemoglobin and other metabolically active compounds that require iron as a constituent or cofactor.
Globally, the most common cause of anemia is iron deficiency. Other possible causes are acute or chronic infections, parasitic diseases, heavy menstruation, hemoglobinopathy, colon cancer, and vitamin A/B12 or folate deficiency, among others.
Various epidemiological studies have shown that iron deficiency anemia is still one of the most prevalent nutritional deficiencies. Iron deficiency is present in up to 30% of women, and 70% of pregnant women. A recent cross-sectional study investigated the prevalence and possible risk factors for iron deficiency anemia on aboriginal schoolchildren living in remote areas in Malaysia. Overall, 48.5% of children were anemic. Low levels of mothers' education and low household income were identified as risk factors; severe trichuriasis was also found to be associated (Al-Mekhlafi 1046).
If this deficiency is present during the first two years of life, a functional disturbance is highly probable, given that the developing brain experiences structural and biochemical changes; a few weeks afte ...Show more