Got a tricky question? Receive an answer from students like you! Try us!

Manuscript Discussion Section - Essay Example

Only on StudentShare
College
Essay
Miscellaneous
Pages 2 (502 words)

Summary

A broad range of endogenous and exogenous molecules interact with neuronal nicotinic acetylcholine receptors (nAChRs) through different binding sites. The agonist binding sites are well characterized and are potential loci of drug design. These nAChRs also contain additional binding sites where allosteric non-competitive antagonists (NCA) located primarily within the membrane receptors…

Extract of sample
Manuscript Discussion Section

In this study affinity chromatographic technique has been used to derive binding affinities. With the application of affinity chromatography to direct determination of functional activities, there is problem with determination of functional activities, indicating the fact that affinity in binding may not be directly correlated with the pharmacological action of the drug on the pharmacological target. In case of competitive agonists and antagonists, these properties are related using Cheng-Prusoff relationship,
where Ki is the binding affinity of the inhibitor, IC50 is the functional strength of the inhibitor, S is substrate concentration, and Km is the affinity of the substrate for the enzyme. The Cheng-Prusoff relationship cannot be used with NCAs due to occurrence of allosteric interactions. The relative antagonistic activities of a series of noncompetitive antagonists, namely, imipramine, ethidiuum, phencyclidine, dextromethorphan, and mecamylamine expressed as IC50 values towards nAChRs can be measured using data from affinity chromatography on an immobilized nAChR stationary phase using nondirect method of multivariate analysis for assessment of IC50 values. ...
Download paper
Not exactly what you need?

Related Essays

Fifth Section
One-year strategic objectives are to identify a market which most effectively exploited its capabilities, the market for cordless segments, and develop this market. The brand in turn should acquire a distinctive identity. That combination, a system of production which gives the company a particular advantage in its chosen market segment, a world-wide reputation for product quality, and a brand which immediately identifies the aims and aspirations of its customers, will make Able Corporation one of the most profitable manufacturers. Five-year strategic objectives are: (1) to develop innovative…
2 pages (502 words)
Online discussion
Yes, this is true.as long as the compliments are taken as genuine. A false compliment or flattery for the sake of influence can cause suspicion and close off the person. Even sincere compliments have to be given with discretion because if the person thinks that you are saying nice things just to get them to do something, they will not be cooperative.…
2 pages (502 words)
Summary of Section 754
Hence, now the owners and managers who pay tax and their advisers now advance towards the transactions with the same concern, as those stated in the historic decrees of subchapter K that the partnerships concerned with tax have been asking for years: why incorporate The substantial increase in the use of partnerships has led to increasing frustration with the obsolete subchapter K regulations (most of which were spread in 1955). Among the most troublesome laws are those which govern the basis for adjustments on the sale or swap (exchange) of a partnership stake (Orbach, 2004). In fact, the…
8 pages (2008 words)
Rousseau Discussion
Personally, I am interested in the balance between individual freedoms and societal needs. I think there are valid social concerns on both sides of this issue and I haven't yet reached a conclusion as to where the line between social safety and individual freedom should be drawn. I am looking forward to this class to inform my opinion and provide insight to the issues.…
2 pages (502 words)