Cellular and Molecular Pathological Mechanisms in the Failing Heart - Article Example

Only on StudentShare

Extract of sample
Cellular and Molecular Pathological Mechanisms in the Failing Heart

In many cases, however, it is not possible to arrive at a specific etiologic diagnosis, and thus it is often more desirable to classify the cardiomyopathies into one of three types dilated, restrictive, hypertrophic on the basis of differences in their pathophysiology and clinical presentation. About one in three cases of congestive heart failure (CHF) is due to dilated cardiomyopathy, with the remainder the consequence of coronary artery disease. Left and/or right ventricular systolic pump function is impaired, leading to progressive cardiac enlargement and hypertrophy, a process called remodeling. Symptoms of CHF typically appear only after remodeling has been ongoing for some time. There is, however, no close correlation between the degree of contractile dysfunction and the severity of symptoms. Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, typically of a nondilated chamber, without obvious cause such as hypertension or aortic stenosis. Two features of HCM have attracted the greatest attention: (1) asymmetric left ventricular hypertrophy, often with preferential hypertrophy of the interventricular septum; and (2) a dynamic left ventricular outflow tract pressure gradient, related to a narrowing of the subaortic area as a consequence of the midsystolic apposition of the anterior mitral valve leaflet against the hypertrophied septum. ...
Download paper


The cardiomyopathies are a group of diseases that affect the heart muscle itself and are not the result of hypertension or congenital or acquired valvular, coronary, or pericardial abnormalities. The term cardiomyopathy should be restricted to a condition primarily involving the myocardium…
Author : devanklocko

Related Essays

Molecular Microbiology
The commoner intravenous catheter-related infections are exit-site infections, as in this case, often with erythema around the area where the line penetrates the skin.
6 pages (1506 words) Case Study
Normal and Pathological mourning
The object thus is to evaluate the understanding of a model of mourning and object loss in the light of academic perspectives and to define a demarcation between normal and pathological mourning. Finally in the light of case studies and examples drawn from academic literature the Paper culminates with an attempt to formulate a diagnostic approach to facilitate better handling of mourning and grief which may turn depressive
34 pages (8534 words) Essay
Cellular Respiration
ATP is called as a "Universal energy currency" since all the energy transactions of the cell use this molecule.
9 pages (2259 words) Essay
Molecular Biology
The results are as follows:
7 pages (1757 words) Lab Report
Discuss the cellular basis of diastolic dysfunction
This phase comprises of the systole. As soon as the systole begins, the mitral and tricuspid valves shut close tightly in order to prevent any backflow of blood into the atria. At the same time, the pulmonary and the aortic valves are pushed open, leading to a flow of blood from right ventricle to lungs and from the left ventricle to the whole body, after getting oxygenated from the lungs.
10 pages (2510 words) Essay
Pathological liar
Once a lie is told, there is no changing it, no taking it back, and no easy resolution to solving the problems that it creates.” If lying becomes habitual and chronic, the liar becomes known to have developed into a compulsive liar. This is differentiated from a pathological liar, which is the topic of this research.
4 pages (1004 words) Research Paper
Molecular Mechanisms of Atrial Fibrillation
Progression in the studies of genetics and molecular biology would assist in dealing with this disease in a better way. Recently studies by Chelu et al (2009) have brought into light the fact that differences in the ionic (mainly Ca 2+) current flow are responsible for causing AF and turning it into a chronic condition. As Brugada points out “Research efforts to elucidate the molecular basis of AF are focused into two main areas: human genetics and alterations in genetic expression of ion channels” (Brugada, Is Atrial fibrillation a genetic disease?: Molecular Mechanisms in Arial...
2 pages (502 words) Essay
Got a tricky question? Receive an answer from students like you! Try us!