Biochemistry - Essay Example

Only on StudentShare

Extract of sample

Deduce the likely enzyme deficiency causing the infant's condition and explain how this deficiency can cause his symptoms. How might you treat this disorder
The lack of the denaturase enzyme results in a build up of unreduced LFA and a increased request of caritine to transport the accumulating waste products. The caritine is then becoming acylated with the LFA which results in low serum caritine and a disruption of fatty acid metabolism overall.
2. Wakil's pioneering studies on the synthesis of fatty acids included the crucial observation that bicarbonate was required for the synthesis of palmitoyl CoA. He was surprised to find that very low levels of bicarbonate could sustain palmitate biosynthesis and that there is no correlation between the amount of bicarbonate required and the amount of palmitate produced. Explain these observations and describe how radiolabelled bicarbonate could be used to support your explanation.
The following reactiom is the accepted mechanism for producing the long chain fatty acid palmitoyl-CoA. When acetyl coenzyme A, malonyl coenzyme A and reduced triphospopyridine nucleotide (TPNH) are used as substrates palmitic acid is the principal product of the reaction. Naturally the reaction is enzymatic. ...
Download paper


An infant patient suffers from hypotonia, poor feeding, and low weight gain. In an effort to diagnose his condition, you examined mitochondria in muscle cells obtained from a biopsy and detect a deficiency in oxidative metabolism. The patient's mitochondria consumed oxygen normally when incubated with pyruvate and malate; succinate; or palmitoyl CoA and carnitine…
Author : sjenkins

Related Essays

The conversion of glucose to glycogen, a process of energy storage, is achieved by a number of enzymes, the absence or deficiency of which leads to the GSDs resulting in inborn errors of glycogen metabolism. These disorders arise due to deficiency of enzymes involved in the glyconeogenesis or due to abnormal functioning of the glycogen breakdown enzymes.
8 pages (2008 words) Essay
Biochemistry Lab Report
The gels were visualized by coomassie staining. The restriction digestion of recombinant DNA yielded the predicted band sizes upon electrophoresis, confirming the presence of the pGLO plasmid in the transformants. The presence of a single neat band at the expected size range upon immunoblotting indicates the successful isolation of the purified GFP protein.
3 pages (753 words) Lab Report
In this way, the larger molecules of the inactive peptide would not be able to bind to the stationary phase and therefore, will be eluted first. And after this, a strong acid exchanger can be used to facilitate the dissociation of the active peptide with the stationary phase.
11 pages (2761 words) Scholarship Essay
Clinical biochemistry Case Study.
Ischemia is manifest most frequently as chest discomfort, which James was having while reduction of the pumping ability of the heart commonly leads to hypotension or syncope, which may be the cause of collapse. Indeed as in the case of James, ischemic heart disease, which is by far the most common form of heart disease in adults, may present with chest discomfort which may be the result of myocardial infarction.
5 pages (1255 words) Case Study
Clinical Biochemistry Essay Short questions(degree)
To diagnose Cushing’s syndrome levels of free cortisol are checked in the urine. Levels of cortisol in the saliva and serum are checked at midnight to confirm the disease. Dexamethasone which is a synthetic glucocorticoid is administered which leads to decreased cortisol if the increased levels are due to a tumor in the anterior pituitary. Addisons disease is characterized by insufficiency of cortisol which is caused mostly due to production of antibodies against the adrenal gland within the body. This leads to decreased glucose metabolism in the body causing hypoglycemia and it can prove to...
2 pages (502 words) Essay
Clinical Biochemistry Essay Questions.
s disease is an autoimmune disorder in which certain antibodies are developed in the body against the thyroid gland which includes thyroid stimulating immunoglobulin (TSI), thyroid growth stimulating immunoglobulin (TGI) and TSH binding inhibitor immunoglobulin (TBII). The TSI antibodies bind to the receptors on the thyroid gland where under normal conditions TSH binds and stimulate the secretion of the thyroid hormone. While bound to the receptor to block the effect of TSH they actually lead to the increased secretion of the thyroid hormone. Because of the increased thyroid hormone low levels...
2 pages (502 words) Essay
Biochemistry Research Essay Paper on MUcolipidoses Diseases ( EXPLAIN BRIEFLY)
Mucolipidosis type 1 (ML 1) known as sialidosis occurs because of a deficiency in sialidase, a critical digestive enzyme. According to Smith, (2013) the rare disease is an inheritation of a defect involving storage by lysosomes. For the cells to function properly glycoproteins should be free from molecules that have sugar content. Sialidase in particular assists in removing sialic acid from forms of sugar proteins (Miedel, 2008). Due to the deficiency of the enzyme, results in molecular that resemble sugar settling in not only the cells but also the neurons and the bone marrow. The body of the...
6 pages (1506 words) Research Paper
Got a tricky question? Receive an answer from students like you! Try us!