Human Growth Hormone Replacement Therapy and Aging

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Synthesized in the anterior pituitary, the human growth hormone, also known as somatotropin, represents an important protein molecule, which promotes growth of many tissues in the body. It also influences several aspects of metabolism, such as increasing protein disposition in the bodies, utilization of fat as an energy source and reducing the use of carbohydrates as a main source of energy.


in 2001. The scientists state that while the reduction of concentration of somatotropin during aging is documented, there were several problems with previous researches as they did not exclude the various gonadotropic hormones that were also reduced with old age. The study was performed on two groups, a young group, consisting of 8 men and 8 women, and an aging group consisting of 11 women and 10 men. All the subjects had similar body mass indexes and blood samples were taken from each of the test subjects every 10 minutes for 24 hours. The results from the research showed a marked decrease of 32-56% of growth hormone concentration, each according to its sex. 81% of the young group secreted the highest amount of growth hormone during the night period, while 62% of the aging group secreted most of the growth hormone during the day period. The researchers reached the conclusion that there is a decrease in secretion of growth hormone as age increases for both sexes. The reduced concentration of growth hormone was, in turn seen as a lack of growth hormone releasing hormone. (Russel-Aulet et al.)
Another research focuses on the problem of sarcopenia, which represents a syndrome that manifests itself as a decrease in skeletal muscle mass, as well ...
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