StudentShare solutions
Got a tricky question? Receive an answer from students like you! Try us!

Essay example - Scientists study how HIV hides in body

Only on StudentShare
College
Essay
Miscellaneous
Pages 2 (502 words)
WASHINGTON - The AIDS virus has hideouts deep in the immune system that today's drugs can't reach. Now scientists finally have discovered how HIV builds one of those fortresses - and they're exploring whether a drug already used to fight a parasite in developing countries just might hold a key to break in.

Extract of sample

Yet those drugs don't eliminate HIV because they can't reach the two known pools of cells where the virus can lie dormant, ever ready to resurface.
So-called memory T cells form one such pool. As the name implies, these are the cells that ensure if you get, say, measles as a child, you're forever immune. They live for years, even decades, making them a logical HIV hideout, and one that scientists have repeatedly sought to dismantle to no avail.
Macrophages, another type of immune cell, form the second pool. They roam the body looking for invaders like bacteria to gobble up. If they get harmed, such as becoming infected by a virus, they're supposed to commit suicide. But HIV instead keeps them alive long past their normal lifespan.
"Up to now, nobody has really thought about how to eliminate the macrophage reservoir," said Dr. Kuan-Teh Jeang, an HIV specialist at the National Institutes of Health. "The imagination now has turned toward, 'How do we eliminate reservoirs' ... The best way to address our problem is to simply kill those cells."
The Rochester team found that HIV produces a protein that turns on a particular cell-survival pathway. After a multistep process, it ultimately activates an enzyme called Akt that in turn prevents cell suicide, the researchers reported Thursday online in the journal Retrovirology.
That was g ...
Download paper
Not exactly what you need?

Related papers

HIV Testing
On the one hand the need for prevention of HIV transmission clearly rectifies the need for antenatal scanning. On the other hand the choice of conduction of the test is in the hands of the patient and not the hospital or healthcare providers. To do so with out the patient's consent would be illegal and undesirable. The psychological and social disadvantages are one of the major concerns for the…
4 pages (1004 words)
HIV/AIDS Essay
In 1982 the term "acquired immunodeficiency syndrome" was coined to describe the array of symptoms noted in individuals with AIDS (AVERT, 2006). The underlying cause of the array is a depressed immune response characterized by the appearance of opportunistic infections (CDC, 2003), so-called because they are caused by organisms which do not cause disease in healthy individuals. People with AIDS…
2 pages (502 words)
Youth HIV prevention
The impact from the HIV/AIDS epidemic, with an estimated 42 million cases worldwide, is only beginning to be felt in the lives of individuals, communities and entire nations. In 2003, an estimated five million people were newly infected with HIV, 3.5 million of these cases occurring in sub-Saharan Africa alone. Not surprisingly, the HIV/AIDS epidemic has been cited as being a "developmental…
38 pages (9538 words)
HIV/AIDS
This CD4-defined tissue tropism explains the major pathological effects of HIV, which are immunodeficiency and neurological disease. However, HIV may also cause damage at sites where CD4 is not expressed. This may be a result of direct infection of CD4-cells, in which low levels of viral replication can occasionally occur, or due to infiltration of tissue by HIV-infected lymphocytes and…
7 pages (1757 words)