Atypical anti-psychotic drugs are commonly used in treating acute mania, bipolar disorder, borderline personality disorder, psychosis, and schizo-affective disorder. (Leslie, Hankey, & Lean, 2007) In line with the adverse health effects of these drugs, several studies show that atypical anti-psychotic medications particularly the Olanzapine and Clozapine; anti-depression drug such as Nortriptyline, Doxepin, and Amitriptyline; Lithium; Valproate; as well as beta-adrenergic blocking agent like Propranolol highly contributes to the excessive weight gain or obesity. (Science Daily, 2008; Leslie, Hankey, & Lean, 2007; Czobor et al., 2002; Rossner et al., 1990)
Obesity is a serious health and social problem since it could cause a person to deal with social adjustment disorders or social discrimination. (Pearce et al., 2002) As a common knowledge, obesity could also increase the risk of a person to suffer from a wide-range of serious health concerns such as diabetes particularly the Type 2 diabetes or the non-insulin dependent diabetes mellitus (NIDDM) (Alberti et al., 2007; Wilding, 2004), cerebral hemorrhage and coronary heart diseases (Nanchahal et al., 2005; Montaye at el., 2000), high blood pressure, athersclerosis and high cholesterol (Yuan et al., 1998; Berenson et al., 1993), atherosclerosis (Nazario, 2007), osteoarthritis (Lau et al., 2000), sleep apnea (Ballington, 2002), as well as cancer (Vainio & Bianchini, 2002) related to colon (Murphy et al. 2000), rectum (Giascosa et al., 1999), post menopausal related breast cancer and uterus (Vainio & Bianchini, 2002; Friedenreich, 2001; van den Brandt et al., 2000; Goodman et al., 1997), kidney (Yuan et al., 1998; Goodman et al., 1997), gallbladder (Lowenfels et al., 1999; Moerman & Bueno-de-Mesquita, 1999), ovaries and pancreas (Vainio & Bianchini, 2002).
Suicidal tendency is considered a major complication that has been associated with the withdrawal from anti-psychotic drugs like