The increase of the elderly population – an inevitable outcome of the aging tendency – has considerable implications for the healthcare practices with care professionals increasingly involved in working with aging patients (Murphy, 2004). Understanding of the nature of major challenges associated with the ageing population is becoming an increasingly critical aspect of modern health care system.
A considerable body of evidence is now available to show that the process of aging is largely due to molecular damage caused by reactive oxygen species, electrophiles, and other reactive endobiotic and xenobiotic metabolites (McEwen et al. 2005). Ageing is associated with the degeneration of functional capacity in all parts of human body, and at all levels of organisation from molecules to complete organ systems. This process is normally referred to as ‘senescence’ and comprises genetic and external factors (Mera 1992).
Quality of life of elderly patients depends more on ageing-related disease than solely on chronological characteristics. ‘Natural’ transformations in the status of the organism during the process of ageing, such as the changes in the immune, cardiovascular and endocrine systems (Martin, & Sheaff 2007), occur simultaneously with pathological processes associated, in their turn, with variety of age-related diseases, such as wear and tear of skin, muscles, and skeleton (Freemont, & Hoyland 2007), cardiovascular system (Greenwald 2007), etc. These two types of changes interact closely in various types of age-related diseases such as hearing loss, noise damage, skin damage, hypertension, increased body mass index, etc (Martin, & Sheaff 2007).
At the cellular level the process of ageing is associated with chromosomal, nucleic acid, protein and other changes (Terman et al. 2007). The pathways involved in these changes have been revealed to possess common features with disease processes. This discovery is very essential for it enables ...Show more