We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.
Nobody downloaded yet

Discuss how the anatomical and molecular structure of the podocyte facilitates filtration in the kidney - Essay Example

Comments (0) Cite this document
Summary
The outer part of the glomerular tuft of the kidneys is the area which has parts of the glomerular capillaries and mesangium which face the urinary space (Kriz…
Download paper
GRAB THE BEST PAPER
Discuss how the anatomical and molecular structure of the podocyte facilitates filtration in the kidney
Read TextPreview

Extract of sample
Discuss how the anatomical and molecular structure of the podocyte facilitates filtration in the kidney

The epithelial cells in the podocytes are polarized in nature with a luminal and basal cell membrane. The cell membrane corresponds to the sole plates of the foot processes. The slit diaphragm is found between the luminal and basal cell membranes (Kriz et al, 1998). A thick surface coat of sialoglycoproteins covers the luminal membrane and the slit diaphragm. The podocytes have a high negative surface charge due to the sialoglycoproteins made up of podocalyxin and podoendin among others. This surface charge helps to maintain the interdigitating pattern of the foot processes. When the surface charge is neutralized by cationic substances like protamine sulphate, the processes draw back and cause tight junctions between them (Kriz et al, 1998). The abluminal membrane contains many proteins participating in the various functions of the glomerulus. Podoplanin is a recently described protein found all over the podocyte. Galatosamine residues of glycoconjugates and A13 (podocyte-specific protein) are found. The cell body has the large nucleus, well developed Golgi system, endoplasmic reticulum and lysosmes (Kriz et al, 1998).Podocytes play a significant role in the physiology and pathology of the glomerulus and form the basis of the filtration process in the kidney along with the slit diaphragm.
The glomerulus has a glomerular filtration barrier which is deeply involved in the kidney functions (Pavenstadt, 2000). The podocyte is the most differentiated cell or highly specialized cell in the glomerulus for the functions. The podocytes stabilize the glomerular architecture by preventing distensions of the glomerular basement membrane and maintain the large filtration surface at the slit diaphragm. They account for 40% of the hydraulic resistance of the filtration barrier (Pavenstadt, 2000). The foot processes are contractile in nature with actin, myosin, alpha-actinin, vinculin and talin and connected to the basement ... Read More
Cite this document
  • APA
  • MLA
  • CHICAGO
(“Discuss how the anatomical and molecular structure of the podocyte Essay”, n.d.)
Retrieved from https://studentshare.net/miscellaneous/382198-discuss-how-the-anatomical-and-molecular-structure-of-the-podocyte-facilitates-filtration-in-the-kidney
(Discuss How the Anatomical and Molecular Structure of the Podocyte Essay)
https://studentshare.net/miscellaneous/382198-discuss-how-the-anatomical-and-molecular-structure-of-the-podocyte-facilitates-filtration-in-the-kidney.
“Discuss How the Anatomical and Molecular Structure of the Podocyte Essay”, n.d. https://studentshare.net/miscellaneous/382198-discuss-how-the-anatomical-and-molecular-structure-of-the-podocyte-facilitates-filtration-in-the-kidney.
  • Cited: 0 times
Comments (0)
Click to create a comment
CHECK THESE SAMPLES - THEY ALSO FIT YOUR TOPIC
Explain how the molecular structure of cell membranes accounts for their selective permeability
The main components of the cell membrane are the lipids and the proteins with the proteins forming a major component of the membrane. Fifty five percent of the cell membrane is constituted by proteins. That is for approximately fifty molecules of lipids, there is one protein molecule present.
8 Pages(2000 words)Essay
How Much is That Kidney in the Window by Bruce Gottliebs
This research aims to evaluate the article “How Much is That Kidney in the Window?” written by Harvard Law School student Bruce Gottlieb published in The New Republic issue dated May 22, 2000. An article presented a relatively radical idea of enforcing a law that would allow people to sell one of their kidneys for profit.
3 Pages(750 words)Essay
Discuss how the molecular clock hypothesis (gene clock, evolutionary clock, or molecular clock) can be used to explain the diver
The molecular clock hypothesis also serves as a null model, which is usable in testing both the rates of mutation and evolution in various species. Molecular clocks continue to influence significantly the development of molecular evolution theories. Following the noted progress in technologies that focus on DNA sequencing, the use of molecular clocks has also experienced a marked increase, allowing for profound effects on the appreciation of the temporal diversification of genomes and species.
8 Pages(2000 words)Essay
Corporate culturism facilitates excellent business performance. Critically discuss this statement
It advances the performance of organization by ensuring larger flexibility and firm pledge from workers. Corporate heritage refers to everything performed in an entrepreneurship business related to its norms, heritage, emblems, systems, convictions, habits, aspires, and objectives.
8 Pages(2000 words)Essay
Kidney Dialysis and Kidney Transplantation
Toxins and other harmful substances, come from various sources such as the environment (in the air, water and other environmental factors), from our food especially those laced with high amounts of preservatives and artificial flavours, from the liquids that we drink such as alcoholic drinks and liquid medicinal preparations, and from imbibed poisons taken in accidentally or intentionally.
4 Pages(1000 words)Essay
Anatomical features
s context, the status of bipedalism in two genera of hominids, Ardipithecus ramidus and Australopithecus afarensis, as seen from the anatomical examination of fossils, makes an interesting study. The discovery of the fossil remains of Ardipithecus ranmidus at Aramis, in the
2 Pages(500 words)Essay
Discuss how the molecular clock hypothesis (gene clock, evolutionary clock, or molecular clock) can be used to explain the divergence of species
Following the noted progress in technologies that focus on DNA sequencing, the use of molecular clocks has also experienced a marked increase, allowing for profound effects on
8 Pages(2000 words)Essay
How dialysis treatment for kidney failure relies on an understanding of the principles of diffusion
Naturally, the kidney organ is a dialyzing organ. When blood passes through the kidney, essential compounds are separated from harmful compounds. Molecules such as urea are small and
6 Pages(1500 words)Essay
A critical discussion on how the value network facilitates firm growth
Attracting capital can also make a strong bargaining right to stabilize growth. For further business growth, the firms need to focus on important aspects that can help in value building. The latter assists a firm to respond
9 Pages(2250 words)Essay
Using either the BCR-ABL oncogene or the ERBB2 (HER2/NEU) oncogene as your example, describe one specific molecular alteration which plays a role in cancer development, and discuss how it has been exploited to improve cancer treatment
The pathological and clinical characteristics of the patients presenting with ERBB2 mutations tend to be more associated with the female gender patients, nonsmokers, patients of Asian origin as well as the
4 Pages(1000 words)Essay
Let us find you another Essay on topic Discuss how the anatomical and molecular structure of the podocyte facilitates filtration in the kidney for FREE!
Contact us:
+16312120006
Contact Us Now
FREE Mobile Apps:
  • About StudentShare
  • Testimonials
  • FAQ
  • Blog
  • Free Essays
  • New Essays
  • Essays
  • The Newest Essay Topics
  • Index samples by all dates
Join us:
Contact Us