This paper will discuss the biological basis of schizophrenia and what has led to that belief.
Schizophrenia is a complex debilitating psychotic disorder that involves a disconnection between thought and language. It affects, thoughts, feeling, perceptions, and overall behavior. The usual onset is age 17 to 25. 90% of those that are being treated are 15-55. Onset before 10 and after 60 is rare (Porth & Matfin, 2008). Recent research and data present a complex image of a brain dysfunction with alterations in anatomic structures as well as protein synthesis and functional disturbances. Some of the manifestations include incomprehensible speech, delusions, hallucinations, and sometimes catatonic behavior. It is thought that sounds and color are more vivid and louder to these patients (Porth, et.al., 2008). There is paranoia as they believe people are watching them or out to get them.
Though the studies following show some research into the neurophysiology of schizophrenic symptoms, it is still virtually unknown what the pathogenesis is. It is known from the imaging techniques being used that there are abnormalities in the construction of the brain but how do those abnormalities relate to the psychological issues. This is still unknown. It will be important to discern at what age this disease begins to manifest itself. One of the studies noted leads the researcher to believe that it may be a manifestation of development in uterus and not occur post partum. Young children are not often scanned so it is not known for sure (Porth, 2008). It is known, however, that adolescents who have a strong family history and who have been scanned do have the larger ventricles shown in a parental scan. Treatment at this time has not changed much though future study may change that. Presently the goal of treatment is still to attempt to induce remission, and improve behavior and cognitive function. Outcomes from the illness are improved and some