He is considered to be the one of the pioneers and the key figures in the development of human immunology. The seven years, which Jules Bordet spent working at the Pasteur Institute became the turning point in the development of his career and paved the way for his scientific triumph. He was able to discover that “bacteriolytic effect of acquired antibody is considerably increased in vivo by the existence of natural serum components” (FAQs).
Soon after joining the Institute, Jules Bordet began exploring the basic problems of human immunology in order to find the ways to defend human organism form different infections. (FAQs). In 1894, one of Bordet’s colleagues discovered that a guinea pig immunized against cholera rapidly died when injected cholera bacteria (FAQs). The discovery of Bordet was outstanding: as he later found out, such problems did occur to guinea pigs only when the bacteria came from a non-immunized pig (FAQs). Moreover, the bacteriolysis did not take place when the antiserum and the bacteria were mixed in a test tube (FAQs). Finally, when Bordet heated the antiserum it immediately lost its power to kill the cholera bacteria (FAQs). In the series of the blood experiments that followed Jules Bordet by injecting red blood cells from one animal species into another species caused the rapid destruction of red cells of the first species by the serum of the second species (FAQs). Later on, Jules Bordet was able to systematize his knowledge of bacteriolysis and to create a general picture of how animal bodies defended themselves against foreign infections (FAQs). On the basis of his discoveries, Bordet created the first complement fixation test, which could determine the presence of various bacteria in an individual’s blood serum (FAQs).
The discovery of the test itself and related discoveries in immunology led Bordet to the best reward: in 1919, Jules Bordet was awarded the