Nucleoside Analogue - Research Paper Example

Only on StudentShare

Extract of sample
Nucleoside Analogue

Despite the remarkable success of this method, the use of lifelong HBIg for hepatitis B prophylaxis has its limitations. Among others are the high cost, limited supply and parental administration. The patient needs to frequently visit the clinic too and requires laboratory monitoring. Another problem with HBIg is it’s a blood product not readily advised by physicians. If a safer non-biological alternative existed, it would have been very easy for the patients. This particular study examined 61 patients that went under donor orthotopic liver transplantation (OLT). The study found that the HBIg cessation a 12 months minimum after the transplant with successive administration of nucleoside and nucleotide analog agent gives an effective prophylaxis against recurring HBV infection. Despite the success of the procedure concerns still persist when applying the same procedure to patients with chronic stable renal dysfunction. One recurrence case in the study seroconverted to HBsAg while being administered oral antivirals (to treat renal dysfunction). Hence renal dysfunction does represent a complication in applying this procedure. ...
Download paper

Summary

Post-transplantation Hepatitis B Prophylaxis with Combination Oral Nucleoside and Nucleotide Analog Therapy S. Saab, S. Desai, D. Tsaoi, F. Durazoa, S. Hana, A. McClune, C. Holt, D. Farmer, L. Goldstein and R. W. Busuttil Article Summary The most common strategy for thwarting Hepatitis B recurrence in the liver transplant patient is using a combination of hepatitis B immune globulin (HBIg) along with an oral antiviral agent like lamivudine…
Author : kcartwright

Related Essays

Pain Management in Cardiac Surgery
Overview of Pain and its Management Pain is a subjective and relatively complex perception that indicates presence or occurrence of tissue damage in the human body. It is the body’s natural response to infection or injury to signal the person that something is damaged in the system (Definition and Types of Pain, 2012). Nociception is the process involved in pain perception where stimuli from potential tissue damage are transmitted through peripheral and central nervous systems (Portenoy and Brennan, 1994). Stimulus begins in the detection of either mechanical, thermal or chemical changes in...
16 pages (4016 words) Essay
Nursing practice
He therefore has to be educated on how the process of chemotherapy takes place and the importance of maintaining good oral hygiene. Even though John follows all the advice from the doctors, he still developed ulcers in his mouth due to chemotherapy. In response to these side effects, the nurses intervene to prevent the worsening of the side effects. Side effects of fluorouracil Fluorouracil is, a drug used in the treatment of cancer. It performs by making an irremediable reserve of thymidylate synthase. It interrupts the action of enzyme blocks hence hinders synthesis of pyrimidine thymidine...
10 pages (2510 words) Essay
HIV: Drug Treatment
The present data point out that intensified AIDS awareness and preventive measures have played a significant role in reducing the number of AIDS deaths and new infections. This paper will evaluate the HIV drug treatment used in the past and the new drug treatments, and how these improvements have altered the role of nurses in health care settings. Past HIV Drug Treatment The first antiviral drug zidovudine (ZDV; AZT) for the prevention of HIV replication was approved by US Food and Drug Administration in 1986. Scientists argued that this drug would prevent HIV replication by restraining the...
5 pages (1255 words) Term Paper
Therapeutic Encounter Essay
She was not taken seriously when she expressed pain and the nurses believed her pain to be mostly psychological. They believed that since she was scheduled for surgery the coming month, she was experiencing some anxiety which manifested as pain. The nurses were opting to delay addressing her concerns because her haemorrhoids were going to be removed anyway. On assessment of patient, my adult nursing background helped me discover that she had a prolapsed uterus hanging out of her anus and it was also very painful and severely inflamed. I requested for stronger pain relievers for the patient and...
6 pages (1506 words) Essay
Nursing Case Study
I have also experienced various treatment procedures of many AIDS patients and faced difficulties while handling these cases, as the professional methods are continuously changing along with the practices that are based on treatment skills. In order to reflect on the subject matter, I have chosen Gibbs reflective model of nursing. Gibbs model of nursing involves a description of the case, evaluation of the treatment experience, diagnostics of patient’s situation, a proposed action plan, and final recommendations (Jasper, 2003). I have also made use of NHIVNA competency to treat an outpatient...
12 pages (3012 words) Essay
Refelction essay
The guiding principles that will be adopted for this reflection will be influenced by Gibbs (1988) model of medical reflection. By an extension, these principles also provide a cyclical model which will enable me to reflect upon this problem and subsequently examine my nursing practice as a founding point for further development and improvement in the nursing profession. Description In this paper I will be reflecting on an experience with a patient who was suffering from urinary tract infection, dehydration and dementia, whom I encountered during my community placement. This patient was...
8 pages (2008 words) Essay
Richard-Campbell Sleep Questionnaire Instrument Critique
In the development of the instrument, studies describing critically ill patients’ patterns of sleep were used as a theoretical basis for various items incorporated into the instrument. The instrument was validated against the polysomnograph and found to be an improvement in measuring sleep quality for patients in intensive care (Richards et al, 2000). ...
5 pages (1255 words) Research Paper
Got a tricky question? Receive an answer from students like you! Try us!