Systemic Lupus Erethematotus - Essay Example

Only on StudentShare

Extract of sample
Systemic Lupus Erethematotus

DISEASE DESCRIPTION Pathophysiology SLE is a chronic, inflammatory, prototypic, systemic autoimmune disease affecting connective tissues such as skin, joints along with kidney and serosal membranes. Researches available indicate an environmental cause, which leads to development of the disease in individuals genetically predisposed and therefore vulnerable to it. However, the disease epidemiology is incompletely understood (Rahman & Isenberg, 2008). The disease involves the production of IgG autoantibodies that are specific for self antigens including DNA, nuclear proteins as well as cytoplasmic components. The disease therefore is characterized by inflammation, vasuclitis, vasculopathy. Further, a deposition of the immune complex especially in the renal glomeruli leads to a systemic inflammatory response through activation of complement (C5), or of Fc{gamma}R-mediated neutrophil and macrophages. While the activation of former leads to formation of membrane attack complexes (C5b-9) or anaphylatoxin and cell activator C5a; that of latter causes release of oxidants and proteases; both leading to injury (KEGG, 2009). ...
Download paper

Summary

SYSTEMIC LUPUS ERYTHEMATOSUS INTRODUCTION Systemic Lupus Erythematosus (SLE), Disseminated lupus erythematosus, Discoid lupus or lupus is a remarkable disease in many aspects; the primary being it is not a single but a protean disease, affecting almost every organ of the body…
Author : clehner

Related Essays

Rheumatoid Arthritis
6 pages (1506 words) Research Paper
Children with Lupus
3 pages (753 words) Article
Children with Lupus have a more lethal form of kidney disease.
8 pages (2008 words) Assignment
Lupus
6 pages (1506 words) Research Paper
Physical Assesment Case Study
4 pages (1004 words) Research Paper
Lupus
5 pages (1255 words) Research Paper
End of life debate
5 pages (1255 words) Essay
Conducting a Lecture
3 pages (753 words) Essay
Diabetes Management Education for a Hispanic female patient
8 pages (2008 words) Term Paper
profeading
1 pages (251 words) Essay
Spirituality
1 pages (251 words) Essay
Chronic Open-Angle Versus Acute Close-Angle Glaucoma
2 pages (502 words) Assignment
Got a tricky question? Receive an answer from students like you! Try us!