Systemic Lupus Erethematotus - Essay Example

Only on StudentShare

Extract of sample
Systemic Lupus Erethematotus

DISEASE DESCRIPTION Pathophysiology SLE is a chronic, inflammatory, prototypic, systemic autoimmune disease affecting connective tissues such as skin, joints along with kidney and serosal membranes. Researches available indicate an environmental cause, which leads to development of the disease in individuals genetically predisposed and therefore vulnerable to it. However, the disease epidemiology is incompletely understood (Rahman & Isenberg, 2008). The disease involves the production of IgG autoantibodies that are specific for self antigens including DNA, nuclear proteins as well as cytoplasmic components. The disease therefore is characterized by inflammation, vasuclitis, vasculopathy. Further, a deposition of the immune complex especially in the renal glomeruli leads to a systemic inflammatory response through activation of complement (C5), or of Fc{gamma}R-mediated neutrophil and macrophages. While the activation of former leads to formation of membrane attack complexes (C5b-9) or anaphylatoxin and cell activator C5a; that of latter causes release of oxidants and proteases; both leading to injury (KEGG, 2009). ...
Download paper

Summary

SYSTEMIC LUPUS ERYTHEMATOSUS INTRODUCTION Systemic Lupus Erythematosus (SLE), Disseminated lupus erythematosus, Discoid lupus or lupus is a remarkable disease in many aspects; the primary being it is not a single but a protean disease, affecting almost every organ of the body…
Author : clehner

Related Essays

Rheumatoid Arthritis
A combination of therapies that include medication, surgury, exercise and adequate rest can help the patients to reduce swelling and pain. This paper discusses the causes, risk factors, occurance in United States, treatment, and medications of rheumatoid arthritis. RHEUMATOID ARTHRITIS INTRODUCTION Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. It is generally seen that the joints become swollen and there is severe pain that is experienced by the patients. Researchers have found that RA causes the immune system of a person to attack their joints. In RA, the autoimmune...
6 pages (1506 words) Research Paper
Children with Lupus
Researchers analyzed data reports “children with lupus kidney disease had more than twice (2.4 times) the risk of dying compared to children with other forms of kidney disease” (para.5). Kidney failure or disease caused by lupus is called Lupus nephritis. This has become a major concern of various medical institute especially lupus related organizations. Last April 14, 2011, the Lupus Foundation of America (LFA) with coordination of RN.com, RxSchool.com, and Dr. Mary Anne Dooley, Member, LFA's Medical-Scientific Advisory Council, launched a new continuing education program for the nurses,...
3 pages (753 words) Article
Children with Lupus have a more lethal form of kidney disease.
In that case, research study may contribute awareness and familiarity, as well as necessary action in handling patients, especially children, with lupus. Relevance of Kidney Disease in Children with Lupus Introduction Systematic Lupus erythematosus (SLE), or Lupus, in its simple term, is a chronic autoimmune disease. Autoimmune disease is an illness that occur when the body’s immune system becomes hyperactive and functions abnormally by attacking various normal and healthy tissues of the body. The body’s immune system is designed to fight bacterial agents and other foreign microbes, or...
8 pages (2008 words) Assignment
Lupus
Lupus is a complex autoimmune disorder affecting numerous bodily systems (Bernknopf, Rowley, & Bailey, 2011). The disease can manifest in clusters of symptoms that have been described as specific syndromes (Zandman-Goddard, Solomon, Rosman, Peeva, & Shoenfeld, 2012). Although there is no cure for the disease, the symptoms caused by lupus can be treated with medications (Bernkopf et al., 2011). There may be an environmentally imposed aspect of the disease in some patients that develop lupus (Zandman-Goddard et al., 2012). ...
6 pages (1506 words) Research Paper
Physical Assesment Case Study
Client was awake, alert and coherent. Physical assessment revealed erythematous plaques covering both cheeks, and at the bridge of her nose, without affecting the nasolabial folds or any other part of her body. Aside from that, her head was found to be normocephalic with no signs of trauma or other deformities. She had clear white sclera and clear conjunctiva; her pupils were reactive to both light and accommodation. Erythema was noted on the posterior wall of her pharynx, and ulcers were found on both of her buccal mucosa. Her neck showed no swelling or bumps, and no traces of lymphadenopathy...
4 pages (1004 words) Research Paper
Lupus
The immune system of a person suffering from lupus cannot differentiate between normal body tissues and antigens. As a result of this, the immune system directs antibodies to normal tissues thinking that they are foreign materials. Due to this, there is swelling and pain felt by the person suffering from this disease. With advanced medical technology, different types of lupus have been identified by doctors. However the most common one is SLE or systemic lupus erythematosus. There are also others known as discoid, neonatal and drug-induced. Symptoms It is important to note that lupus is very...
5 pages (1255 words) Research Paper
End of life debate
Various studies (Lee et al, 2010; Petri and Lazaro, 2009; Edworthy, 2005; and Ticaniet. Al, 2006) suggest that signs and symptoms commonly identified were butterfly rash over cheeks, photosensitivity, erythematous rash to areas exposed to sun, fatigue, malaise, early bruising, sudden weight gain or loss, hair loss, Raynaud’s phenomenon, joint pain and swelling, ulcers of the mouth and nose, plueritis, pericarditis, low grade fever, diarrhea and nausea and vomiting, hence identified as having multisystem effects. By this, SLE is considered to be one of the most serious rheumatic diseases...
5 pages (1255 words) Essay
Got a tricky question? Receive an answer from students like you! Try us!