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Pharmacology Effectiveness of streptokinase in Acute Miocardial Infarction
Pages 8 (2008 words)
Pharmacology Effectiveness of streptokinase in Acute Miocardial Infarction Abstract: Acute myocardial infarction can be treated using streptokinase. Streptokinase is derived from Streptococci. This Enzyme is a protein that binds to the plasmingoen and induces the thrombolysis…
The administration of aspirin and heparin before the treatment will increase the survival rate. Introduction: Acute myocardial infraction is the breakdown of the heart muscles due to the lack of oxygen supply. The shortage in oxygen supply is caused by the collection of lipids at the heart muscles. This creates a block in the blood vessels resulting in ischemia and if left untreated it results in infraction of the myocardial cells. The risk factors of acute myocardial infarction (AMI) are cardiovascular disease, tobacco smoking, older age, kidney diseases, blood pressure, excessive alcohol consumption and obesity. Streptokinase is one of the first thrombolytic agent to be used for the treatment of Acute myocardial infarction. Streptokinase was discovered in the year 1933 by Dr. William Smith Tillett. The use of Streptokinase for the treatment of acute myocardial infarction started in the year 1947 when Sol Sherry identified the potential of streptokinase. (Sikri and Bardia, 2007).The clinical trials using streptokinase started thereafter. They concluded that streptokinase can be used to treat hemothorax, purulent and sanguineous pleural exudations, fibrinous and tuberculosis meningitis. (Sikri and Bardia, 2007).The difficulties in purifying the protein streptokinase led to the delay in the intravenous use. The intravenous use of streptokinase was started in the year 1952. This proved to be a promising approach. ...
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