Research Critique-Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium–glucose co-transporter type 2, in Japanese subjects without and with type 2diabetes mellitus
The use of documented research for study and replication purposes is…
It also helps in assessing the validity and reliability of researches under review as well as their compliance to ethics depending on the methodologies and procedures applied (Burns & Grove, 2011). This paper reviews various aspects of a medical trial study carried out in Japan. The critique evaluates issues of human protection, data collection, analyses and management as well as the final findings. The study by Boulton et al. (2011) highlights the comparative use of dapagliflozin on two treatment groups consisting of diabetics with type II diabetes (T2DM) and healthy subjects. The research paper was published in the fourth issue of the Diabetes, Obesity and Metabolism Journal in 2011. The main objective of the research was to investigate the tolerability and safety of dapagliflozin in the Japanese participants. Evaluated aspects included the pharmacodynamics (PD) and pharmacokinetics (PK) of the drug on both treatment groups.
The implicitly implied benefits of this research included the ability to determine the tolerability and safety of the drug for Japanese subjects, and thus offer a reliable, non-insulin dependent therapeutic option for T2DM management. This would be beneficial because it would save patients with T2DM from regular insulin injections and costs if it would be established as an efficient mono-therapy option or improving add-on to other diabetic therapies. The authors of the research recognized drug allergy as a potential risk and possible aggravation of cardiovascular and diabetic ketoacidocis. As such, precautionary measures were taken to exclude subjects with such conditions or a history of such conditions. In addition to the highlighted benefits, the researchers failed to note that dapagliflozin’s effectiveness does not depend on the dysfunction severity of beta cells. Unlike most other therapies, its effectiveness will not decrease with beta cell failure advancement or with higher severity of insulin resistance. ...
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