This paper describes the pathophysiological changes that occur in Waterhouse Friderichsen and ethical issues surrounding the end-of-life for persons affected by this condition. Therefore, the paper has two sections; description of the pathophysiological systemic condition and end of life debate…
As the discussion highlights the hypothetical case study will be a 35-year-old female patient who was found with signs and symptoms associated with Waterhouse Friderichsen. A 35-year-old female patient got admitted after showing signs of high-grade fever accompanied by chills and vomiting over a period of 7days. The patient also had a skin rash on the abdomen and trunk, which appeared on the 5th day of infection. Following admission, the patient developed a hemorrhagic rash. On assessing the family history, there was no any significant information to associate the infection with family history. Medical examination revealed that the patient was unstable, and there was the presence of cyanosis. The patient was afebrile with a pulse rate of 90/min and a systolic BP of 70mmHg.
From this paper, it is clear that neurological examination revealed positive signs of Kerning and Brudzinski. There were rashes all over the body but predominated on the abdomen and trunk. Collection of CSF was done under aseptic conditions and its processing is done under standard bacteriological procedures. Microscopy on CSF was done routinely, and a cell count of 9400/mm3 was reported. Of the total cell count, 86% were polymorphs while 14% were lymphocytes. An increase in CSF proteins to 309mg% and a decrease in glucose to 20mg% were reported. A Gram stain preparation of the CSF revealed pus cells accompanied with gram-negative diplococcus. CSF cultures were done on MacConkey agar, chocolate agar, and blood agar and incubated overnight. After overnight incubation, there were tiny translucent colonies on blood agar and chocolate agar. Standard bacteriological procedures identified the tinny translucent colonies to be those of Neisseria meningitides. A CT scan conducted on the patient confirmed adrenal hemorrhage, which is present in Waterhouse Friderrichsen syndrome. Antibiotic sensitivity using 5 antibiotics showed no resistance to any of the antibiotics under examination. ...
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This paper describes the pathophysiological changes that occur in Waterhouse Friderichsen and ethical issues surrounding the end-of-life for persons affected by this condition. Therefore, the paper has two sections; description of the pathophysiological systemic condition and end of life debate.
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