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Evidence-Based Practice Paper and Intervention Presentation on Diabetes (Benchmark Assessment) - Essay Example

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The condition may present itself in three different forms including type I diabetes, type II diabetes and gestational diabetes. Type I DM is a result of the body’s failure to produce insulin, whereas; type II DM is a…
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Evidence-Based Practice Paper and Intervention Presentation on Diabetes (Benchmark Assessment)

is diagnostic mode is effective in detecting diabetics and pre-diabetics, but it does not offer a clear mode of assessing resultant complications, which often start in the vascular system. The diagnosis therefore, only tests tolerance to glucose, and not the associated risks such as the vascular risks (Pavri, 2001). The further assessment of risk may be necessary in monitoring the condition and administration of treatment, but it has not been available. However, a recent research by Zampetaki and others has led to the discovery of biomarkers that can be used in diagnosing and monitoring type II diabetes and its associated risk (Zampetaki et al., 2010).
The new diagnostic tool uses microarray screening and real-time polymerase chain reaction (PCR) processes to monitor MicroRNAs (miRNAs), which have been positively associated with the development of the condition and its progression. This new tool offers significant prognostic ability to predict and monitor type II DM. The miRNAs are small group of RNAs not involved in coding. They instead work as repressors in translation (Zampetaki et al., 2010). The miRNAs bind to complementing sites by base pairing on untranslated portions of the target mRNA. They are responsible for directing repression or degradation of the transcripts. Research has shown that miRNAs influence stress responses, oncogenesis, development and angiogenesis. They also play a significant role in endothelial cell functioning as well as the regulation of angiogenic potential and inflammations. The study found that miRNAs change prior to the start of type II DM (Zampetaki et al., 2010). The changes were narrowed to miRNA-126, which was found to profoundly change with type II DM (Larkin, 2010). This provided proof for a plasma Micro-RNA signature for patients with type II DM, thus suggesting a possible prognostic value in monitoring and diagnosing DM (Zampetaki et al., 2010).
The study on miRNAs and DM was part of a wider Italy-based Bruneck Research ... Read More
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