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Pharmacological Management of Major Depression in Older Adults Using Selective Serotonin-Reuptakes Inhibitors
Pages 9 (2259 words)
Pharmacological Management of major Depression in older adults using Selective Serotonin-Reuptakes Inhibitors" Abstract Serotonin-specific re-uptake inhibitors (SSRI) belong to the category of antidepressant drugs that have revolutionized the treatment of depression and significantly minimized the range of adverse effects enforced by the use of the tricyclics or MAOIs.
They have minimal effect on noradrenalin and dopamine activity, compared to the tricyclics or MAOIs. Some of the drugs, like fluoxetine, have a mood elevating effect when used in healthy individuals. Fluoxetine drug has the longest half-life amongst all approved SSRIs with drug and side effects persisting up to six weeks after the termination of therapy. Introduction Serotonin is an important neurotransmitter, a local hormone in the gut, a component of the platelet clotting process, and is thought to play a role in migraine headache. Serotonin is also one of the mediators of the signs and symptoms of carcinoid syndrome, an usual manifestation of carcinoid tumor, a neoplasm of enterochromaffin cells. Patients with non-operable tumor, take serotonin antagonist for a useful treatment. The diagnosis of depression still rests primarily on the clinical interview. Major depressive disorder (MDD) is characterized by depressed mood most of the time for at least 2 weeks and/ or loss of interest or pleasure in most activities. Additionally, depression is associated with sleep, as well as diet disturbances and deficits in cognition and energy. Thoughts of guild, worthlessness and suicide are common. ...
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