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Quantitative critique - Research Paper Example

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The authors state that the issue regarding atypical antipsychotics and metabolic disease has been previously clarified, it has only been in a general way. The authors feel that the distinction between these atypical medications and the comorbidity with weight gain and diabetes…
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Quantitative research critique
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Quantitative critique

The references cited, while not extensive, are suitable for the size of the study. Twenty-two references are used directly. Of these, seven are directly related to the effects the study is analyzing. The others relate to the specific mediations under study as well as the general information regarding diabetes and adiposity. Twenty are current and date from 2002 forward, only two are older, (1) the American Diabetes Association’s “Report of the expert committee on the diagnosis and classification of diabetes mellitus.” dates from 1997 but is only used as a general reference and (2) Gray and Fujioka (1991) “Use of relative weight and body mass index for the determination of adiposity,” also for general guidelines. The review successfully analyzes all the variables in the study. It also cites studies which appear to have already reviewed the topic and presented a direct correlation between these drugs and diabetes/weight gain. In Cohen’s (2004) review of the existing literature he cites that:
…22 cases of new-onset diabetes that resolved and 6 that did not when the antipsychotic was stopped. In a survey of diabetes associated with clozapine, glycemic control improved after clozapine was stopped in 78% of individuals who developed diabetes; 62% of these patients no longer required hypoglycemic drugs. Of 12 patients who were restarted on clozapine, 9 developed hyperglycemia again. (Cohen, 2004, 3)
While other references used generalized this effect there is other literature that directly supports it. For instance, in a study they did not reference, Koller and Doraiswamy (2002) showed in their research that 78% of the group had improved glycemic balance once they stopped taking or decreased the dosage of olanzapine and that if olanzapine was restarted eight out of ten patients had a recurrence of hyperglycemia. So it is clear that there were previous studies which connected the same inferences the authors are ... Read More
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