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Article Summary: Psychoneuroimmunology of Irritable Bowel Syndrome
Pages 3 (753 words)
Article Summary Psychoneuroimmunology of Irritable Bowel Syndrome Your name Your institution Psychoneuroimmunology of Irritable Bowel Syndrome Irritable Bowel Syndrome (IBS) is a disease that represents a heterogeneous group of patients with a similar set of symptoms…
This paper shall summarize the findings of a review article (Arebi, Gurmany, Bullas, Hobson, Stagg, & Kamm, 2008) that discussed the relationship of psychoneuroimmunology to the pathophysiology of Irritable Bowel Syndrome (IBS). Irritable Bowel Syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract, which affects about 10-15% of the world’s population. The characteristic features of the disease are intermittent bouts of abdominal pain, accompanied by abnormal stool frequency and/or consistency. Two main pathophysiologic mechanisms for IBD have been proposed: the first is the gut-directed model, which implicates enteric bacteria,immune activation, visceral hypersensitivity and gut dysmotility to interact and culminate in producing abdominal pain and constipation or diarrhea. The second is the brain-directed model, which discusses psychoneuroimmunologic factors leading to development of IBS. There is a strong association between psychological disorders and IBS. Previous psychological trauma, depression, anxiety and personality disorders are frequent among IBS patients. IBS patients have increased activity in brain areas for affect and attention, which are also stimulated by noxious stimuli. ...
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