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Research Critique - Dapagliflozin Trials
Pages 4 (1004 words)
Running Head: Research Critique-Dapagliflozin Trials. Research Critique-Pharmacokinetics and pharmacodynamics of dapagliflozin, a novel selective inhibitor of sodium–glucose co-transporter type 2, in Japanese subjects without and with type 2diabetes mellitus Name: Course Title: Instructor’s Name: Institution: Date: Introduction The use of documented research for study and replication purposes is meant to develop knowledge in research and enhance better understanding of how researches are carried out and the procedures undertaken to attain the results (Greenhalgh, 2010).
This paper reviews various aspects of a medical trial study carried out in Japan. The critique evaluates issues of human protection, data collection, analyses and management as well as the final findings. The study by Boulton et al. (2011) highlights the comparative use of dapagliflozin on two treatment groups consisting of diabetics with type II diabetes (T2DM) and healthy subjects. The research paper was published in the fourth issue of the Diabetes, Obesity and Metabolism Journal in 2011. The main objective of the research was to investigate the tolerability and safety of dapagliflozin in the Japanese participants. Evaluated aspects included the pharmacodynamics (PD) and pharmacokinetics (PK) of the drug on both treatment groups. Protection of Human Participants The implicitly implied benefits of this research included the ability to determine the tolerability and safety of the drug for Japanese subjects, and thus offer a reliable, non-insulin dependent therapeutic option for T2DM management. ...
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