In conducting a search for research studies in diagnosing dementia and Alzheimer’s disease, it became clear that the majority of research concerns literature reviews of older studies concerning such diagnostic determinations. Additionally, much of the research available for…
A personal research review model (Appendix A: rubric) was created to provide a linear process discussion of the relevant questions. The burning PICOT question for this paper and subsequent research is:
“In elderly people (P=70+), how are cognitive skills measured in dementia and potential Alzheimer’s disease (I=Issue), as compared to younger adults (C), affect the lifestyle of those diagnosed (O), and how long before a diagnosed patient is no longer legally or medically functional (T)?” (Melnyk & Fineout-Overholt 2011).
Funding for this research was provided by Neurosciences Victoria, Austin Hospital Medical Research Foundation, and the Commonwealth Government of Australia Department of Health and Ageing, with unrestricted educational research grants. Funding was also provided by the Commonwealth Government of Australia to publish under Open Access (Pike et al., 2007).
The main reason for conducting this research study (Pike et al., 2007) was to find common bio-indicators in a currently healthy aging senior which provides a predication for eventually moving into dementia and/or Alzheimer’s disease (AD). The β-amyloid (Aβ) presentation is commonly found in those diagnosed with AD, yet it can also occur in normal healthy aging adults as well without affecting the person in any manner. The 11C-PIB-PET brain scan was used in the study to provide a qualitative marking process with three groups: the healthy ageing (HA) adults, the mild cognitive impaired (MCI) adults, and those diagnosed with AD (Pike et al., 2007). Many of the previous research studies have only used formally diagnosed patients with dementia or AD. PIB stands for Pittsburgh Compound B, which is a benzothiazole derivative that will bind to Aβ and is seen during the positron emission tomography (PET) imaging process, also known as the 11C-PIB-PET brain scan (Pike et al., 2007; Kadir et al., 2011). While ageing ...
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