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pathophysiology of diverticulitis
Pages 4 (1004 words)
Pathophysiology of Diverticulitis Inflammation of diverticula is diverticulitis (Simpson and Spiller, 2007). Diverticula are nothing but small herniations in the mucosa that protrude through the layers of the intestine including the smooth muscle along the various natural openings that are created either by vasa recta or nutrient vessels in the intestinal wall (Stollman and Raskin, 2004).
The exact pathogenesis of diverticulitis is yet unknown (Hobson and Roberts, 2004). An insight into the structural changes in the diverticular disease has been found through studies on various postmortem and surgical specimens (Sheth et al, 2008). Initially, gastroenterologists proposed that a fecolith obstructing an abscessed diverticulum led to diverticulitis. However, in 1976, Sethbhakdi reported that studies on resected sigmoid diverticulitis specimens failed to support fecolith based pathogenesis theory. Infact, according to the author, these studies found perforation of the fundus of the diverticulum associated with pericolic or peridiverticular inflammmation in the resected specimens (Sethbhakdi, 1976). Also, 30 percent of the specimens showed no features of inflammation, but showed thickening of the intestinal wall (Sethbhakdi, 1976). The thickened and contracted colon part is known as mychosis. Mychosis was initially thought to be due to muscular hypertrophy. But now, it is understood to be due to elastin deposition and shortening of the bowel. Elastin deposition is thought to be due to increased uptake of a specific substance called proline from the Western diets (Sheth et al, 2008). ...
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